Abstract
The objective of this study was to clarify the etiology of acute cholecystitis and the role of bacteria in the bile in this condition. We evaluated 52 patients with acute cholecystitis; 46 had cholesterol stones and 6 had no claculi. In the presence of cystic duct obstruction, circulatory disturbance occurs gradually, but circulatory disturbance alone cannot cause severe inflammation unless a bacterial infection is present. If there is no obstruction, rapid circulatory disturbance produces necrotic changes of the gallbladder wall, which are implicated in a fulminant course. In both instances, bacterial infection may play an important role in fulminant cholecystitis. Bacteria implicated in acute cholecystitis are usually present in the bile before the onset of this disease.
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Matsushiro, T., Sato, T., Umezawa, A. et al. Pathogenesis and the role of bacteria in acute cholecystitis. J Hep Bil Pancr Surg 4, 91–94 (1997). https://doi.org/10.1007/BF01211348
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DOI: https://doi.org/10.1007/BF01211348