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Significance of urinaryN 1,N 8-diacetylspermidine andN 1,N 12-diacetylspermine as indicators of neoplastic diseases

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Abstract

N 1,N 8-Diacetylspermidine (Ac2Spd) andN 1,N 12 diacetylspermine (Ac2Spm), the occurrence of which in healthy human urine was demonstrated recently, increased much more frequently and markedly than total polyamines, acetylputrescine,N 1-acetylspermidine andN 8-acetylspermidine in patients with urogenital malignancies. Ac2Spd was hardly elevated in cases of benign disease, while Ac2Spm only infrequently stayed within normal limits in patients with malignant disorders. Urine samples from more than 90% of healthy persons, but fewer than 10% of patients with malignancies, gave values within normal limits for both Ac2Spd and Ac2Spm. Simultaneous reference to these diacetylpolyamines is therefore useful in distinguishing patients with malignancies from healthy persons.

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Abbreviations

Ac 2 Spd N 1 :

N 8-diacetylspermidine

Ac 2 Spm N 1 :

N 12-diacetylspermine

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Authors and Affiliations

  1. Selt Defense Force Central Hospital, 1-2-24 Ikejiri, 154, Setagaya-ku, Tokyo, Japan

    Masayuki Sugimoto

  2. The Tokyo Metropolitan Institute of Medical Science, 3-18-22 Honkomagome, 113, Bunkyo-ku, Tokyo, Japan

    Kyoko Hiramatsu, Masato Hoshino, Kentaro Iwasaki & Masao Kawakita

  3. School of Allied Health Science, Faculty of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, 113, Bunkyo-ku, Tokyo, Japan

    Sachiko Kamei

  4. Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, 113, Bunkyo-ku, Tokyo, Japan

    Kenji Kinoshita

Authors
  1. Masayuki Sugimoto
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  2. Kyoko Hiramatsu
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  3. Sachiko Kamei
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  4. Kenji Kinoshita
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  5. Masato Hoshino
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  6. Kentaro Iwasaki
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  7. Masao Kawakita
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Sugimoto, M., Hiramatsu, K., Kamei, S. et al. Significance of urinaryN 1,N 8-diacetylspermidine andN 1,N 12-diacetylspermine as indicators of neoplastic diseases. J Cancer Res Clin Oncol 121, 317–319 (1995). https://doi.org/10.1007/BF01209602

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  • DOI: https://doi.org/10.1007/BF01209602

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