Skip to main content
SpringerLink
Log in

Binding of alkaline earth metal ions to nucleotides: crystal structure of a hydrated strontium salt of inosine-5′-monophosphate

  • Published:
Journal of Crystal and Molecular Structure Aims and scope Submit manuscript

Abstract

Crystals of Sr2+ (C10H11PN4O8)2− · 6.5H2O are orthorhombic, space groupP212121, witha = 21.925(1),b = 21.503(1),c = 8.600(1) Å, and eight formula weights per unit cell. A trial structure was obtained by Patterson, superposition, and Fourier techniques and was refined by full-matrix least-squares calculations using absorption-corrected, CuKα, diffractometer data. The finalR index is 0.032. A strontium ion is coordinated to N(7), the site that is often involved in the binding of transition metals to purine nucleotides. Strontium ions are also directly coordinated to a phosphate-oxygen atom and to ribose-hydroxyl groups. These direct interactions are accompanied by a number of outer-sphere, water-mediated contacts of strontium ions with various acceptor sites on the nucleotides.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Brown, E. A., and Bugg, C. E. (1980)Acta Cryst. B, in press.

  • Bugg, C. E., Thomas, J. M., Sundaralingam, M., and Rao, S. T. (1971)Biopolymers 10, 175–219.

    Google Scholar 

  • Busing, W. R., Martin, K. O., and Levy, H. A. (1972)Orfls. ORNL-TM305, Oak Ridge National Laboratory, Oak Ridge, Tennessee.

    Google Scholar 

  • Busing, W. R. (1971)Acta Cryst. A 27, 683–684.

    Google Scholar 

  • Coppens, P., and Hamilton, W. C. (1970)Acta Cryst. A 26, 71–83.

    Google Scholar 

  • Donohue, J., and Trueblood, K. N. (1960)J. Mol. Biol. 2, 363–371.

    Google Scholar 

  • International Tables for X-Ray Crystallography (1974) Vol. IV, Tables 2.2A and 2.3.1 (Kynoch Press, Birmingham).

  • Izatt, R. M., Christensen, J. J., and Rytting, J. H. (1971)Chem.-Rev. 71, 439–481.

    Google Scholar 

  • Johnson, C. K. (1965)Ortep. ORNL-3794. ORNL-3794, Oak Ridge National Laboratory, Oak Ridge, Tennessee.

    Google Scholar 

  • Marzilli, L. G. (1977) inProgress in Inorganic Chemistry, Vol. 23, S. J. Lippard, ed. (Wiley, New York), pp. 255–378.

    Google Scholar 

  • Nagashima, N., and Iitaka, Y. (1968)Acta Cryst. B 24, 1136–1138.

    Google Scholar 

  • Phillips, R. (1966)Chem. Rev. 66, 501–527.

    Google Scholar 

  • Saenger, W. (1973)Angew. Chem. 12, 591–601.

    Google Scholar 

  • Stewart, R. F., Davidson, E. R., and Simpson, W. R. (1965)J. Chem. Phys. 42, 3175–3187.

    Google Scholar 

  • Sundaralingam, M. (1969)Biopolymers 7, 821–860.

    Google Scholar 

  • Tu, A. R., and Heller, M. J. (1974) inMetal Ions in Biological Systems, Vol. I, H. Sigel, ed. (Marcel Dekker, New York), pp. 1–49.

    Google Scholar 

  • Wehe, D. J., Busing, W. R., and Levy, H. A. (1962)Orabs. ORNL-TM-229, Oak Ridge, National Laboratory, Oak Ridge, Tennessee.

    Google Scholar 

  • Wilson, A. J. C. (1942)Nature (London) 150, 151–152.

    Google Scholar 

  • Zachariasen, W. H. (1963)Acta Cryst. 16, 1138–1139.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Dental Research and Department of Biochemistry, University of Alabama in Birmingham, University Station, 35294, Birmingham, Alabama

    Edwin A. Brown & Charles E. Bugg

Authors
  1. Edwin A. Brown
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Charles E. Bugg
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Brown, E.A., Bugg, C.E. Binding of alkaline earth metal ions to nucleotides: crystal structure of a hydrated strontium salt of inosine-5′-monophosphate. Journal of Crystal and Molecular Structure 10, 19–30 (1980). https://doi.org/10.1007/BF01209550

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01209550

Keywords

Search

Navigation