Skip to main content
SpringerLink
Log in

Signal transduction: Evolution of an idea

  • Published:
Bioscience Reports

Abstract

“In general there is no set of observations conceivable which can give enough information about the past of a system to give complete information as to its future”: Norbert Wiener. “Think simplicity; then discard it”: Alfred North Whitehead

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Rodbell, M. (1964)J. Biol. Chem. 239:375–380.

    PubMed  Google Scholar 

  2. Rodbell, M. (1966)J. Biol. Chem. 241:130–139.

    PubMed  Google Scholar 

  3. Rodbell, M. and Jones, A. B. (1966)J. Biol. Chem. 241:140–143.

    PubMed  Google Scholar 

  4. Rodbell, M., Jones, A. B., Chiappe de Cingolani, E. E. and Birnbaumer, L. (1968)Rec. Progr. Hormone Res. 24:215.

    Google Scholar 

  5. Berridge, M. J. and Irvine, R. F. (1984)Nature 312:315–321.

    PubMed  Google Scholar 

  6. Sutherland, E. W., Rall, T. W. and Menon, T. (1962)J. Biol. Chem. 237:1220–1227.

    PubMed  Google Scholar 

  7. Sutherland, E. W. and Robison, G. A. (1966)Pharmacol. Rev. 18:145–161.

    PubMed  Google Scholar 

  8. Monod, J., Changeux, J. P. and Jacob, F. (1963)J. Mol. Biol. 6:306–329.

    PubMed  Google Scholar 

  9. Krishna, G., Weiss, B. and Brodie, B. B. (1968)J. Pharmacol. Exp. Ther. 163:379–386.

    PubMed  Google Scholar 

  10. Salomon, Y., Londos, C. and Rodbell, M. (1974)Anal. Biochem. 58:541–548.

    PubMed  Google Scholar 

  11. Rodbell, M. (1967)J. Biol. Chem. 242:5757.

    PubMed  Google Scholar 

  12. Birnbaumer, L., Pohl, S. L. and Rodbell, M. (1969)J. Biol. Chem. 244:3468–3476.

    PubMed  Google Scholar 

  13. Birnbaumer, L. and Rodbell, M. (1969)J. Biol. Chem. 244:3477–3482.

    PubMed  Google Scholar 

  14. Bär, H. P. and Hechter, O. (1969)Proc. Natl. Acad. Sci. USA 63:350–356.

    PubMed  Google Scholar 

  15. Birnbaumer, L., Pohl, S. L., Krans, H. M. J. and Rodbell, M. 1970. In:Advances in Biochemical Psychopharmacology (P. Greengard and E. Costa, editors). Raven Press, New York. 185–208.

    Google Scholar 

  16. Wiener, N. (1961). Cybernetics, MIT Press, Cambridge, Mass.

    Google Scholar 

  17. Hechter, O. and Halkerston, I. D. K. (1964). In:The Hormones, Vol. V. (G. Pincus, K. V. Thiman and E. B. Astwood, editors). Academic Press, New York. 697–825.

    Google Scholar 

  18. Neville, D. (1968)Biochim. Biophys. Acta 154:540–546.

    PubMed  Google Scholar 

  19. Rodbell, M., Krans, H. M. J., Pohl, S. L. and Birnbaumer, L. (1971)J. Biol. Chem. 246:1872–1876.

    PubMed  Google Scholar 

  20. Rodbell, M., Birnbaumer, L., Pohl, S. L. and Krans, H. M. J. (1971)J. Biol. Chem. 246:1877–1882.

    PubMed  Google Scholar 

  21. Rodbell, M., Lin, M. C. and Salomon, Y. (1974)J. Biol. Chem. 249:59–65.

    PubMed  Google Scholar 

  22. Londos, C., Salomon, Y., Lin, M. C., Harwood, J. P., Schramm, M., Wolff, J. and Rodbell, M. (1974)Proc. Natl. Acad. Sci. USA 71:3087–3090.

    PubMed  Google Scholar 

  23. Salomon, Y. and Rodbell, M. (1975)J. Biol. Chem. 250:7245–7250.

    PubMed  Google Scholar 

  24. Rendell, M. S., Rodbell, M. and Berman, M. (1977)J. Biol. Chem. 252:7909–7912.

    PubMed  Google Scholar 

  25. Schramm, M. and Rodbell, M. (1975)J. Biol. Chem. 250:2233–2237.

    Google Scholar 

  26. Cassel, D., Levkovitz, H. and Selinger, Z. (1977).J. Cyclic Nucleotide Res. 3:393–406.

    PubMed  Google Scholar 

  27. Ting, T. D. and Ho, Y. K. (1991)Biochemistry 30:8996–9007.

    PubMed  Google Scholar 

  28. Harwood, J. P., Low, H. and Rodbell, M. (1973)J. Biol. Chem. 254:6239–6245.

    Google Scholar 

  29. Harwood, J. P. and Rodbell, M. (1973)J Biol. Chem. 248:4901–4904.

    PubMed  Google Scholar 

  30. Yamamura, H., Lad, P. M. and Rodbell, M. (1977)J. Biol. Chem. 252:7964–7966.

    PubMed  Google Scholar 

  31. Cooper, D. M. F., Schlegel, W., Lin, M. C. and Rodbell, M. (1979)J. Biol. Chem. 254:8927–8931.

    PubMed  Google Scholar 

  32. Londos, C. and Wolff, J. (1977).Proc. Natl. Acad. Sci. USA 74:5482–5486.

    PubMed  Google Scholar 

  33. Rodbell, M. (1980)Nature 284:17–22.

    PubMed  Google Scholar 

  34. Pfeuffer, T. (1977)J. Biol. Chem. 252:7224–7234.

    PubMed  Google Scholar 

  35. Pfeuffer, T. and Helmreich, J. M. (1975)J. Biol. Chem. 250:867–876.

    PubMed  Google Scholar 

  36. Gill, D. M. (1977)Adv. Cyclic Nucleotide Res. 8:85–118.

    PubMed  Google Scholar 

  37. Katada, T. and Ui, M. (1982).Proc. Natl. Acad. Sci. USA 79:3129–3133.

    PubMed  Google Scholar 

  38. Daniel, V., Litwack, G. and Tomkins, G. M. (1973)Proc. Natl. Acad. Sci. USA 70:76–79.

    PubMed  Google Scholar 

  39. Bourne, H. R., Coffino, P. and Tomkins, G. M. (1975)Science 187:750–752.

    PubMed  Google Scholar 

  40. Ross, E. M. and Gilman, A. G. (1977)J. Biol. Chem. 252:6966–6969.

    PubMed  Google Scholar 

  41. Ross, E. M., Howlett, A. C. and Gilman, A. G. (1978)J. Biol. Chem. 253:6401–6412.

    PubMed  Google Scholar 

  42. Lad, P. M., Welton, A. F. and Rodbell, M. (1977)J. Biol. Chem. 252:5942–5946.

    PubMed  Google Scholar 

  43. Welton, A. E., Lad, P. M., Newby, A. C., Yamamura, H., Nicosia, S. and Rodbell, M. (1977)J. Biol. Chem. 252:5947–5950.

    PubMed  Google Scholar 

  44. Bitensky, M. W., Wheeler, G. L., Aloni, B., Vetury, S. and Matuo, Y. (1978)Adv. Cyclic Nudeotide Res. 9:553–572.

    Google Scholar 

  45. Goodhardt, M., Ferry, N., Geynet, P. and Hanoune, J. (1982)J. Biol. Chem. 257:11577–11581.

    PubMed  Google Scholar 

  46. Fung, B. K. K. (1983)J. Biol. Chem. 258:10495–10502.

    PubMed  Google Scholar 

  47. Gilman, A. G. (1987)Annu Rev Biochem 56:615–650.

    PubMed  Google Scholar 

  48. Tolkovsky, A. M. and Levitzki, A. (1978)Biochemistry 17:3795–3810.

    PubMed  Google Scholar 

  49. Neubig, R. R. (1994)FASEB J. 8:939–946.

    PubMed  Google Scholar 

  50. Houslay, G. A., Ellory, J. C., Smith, G. A., Hesketh, T. R., Stein, J. M., Warren, G. B. and Metcalfe, J. C. (1977)Biochim. Biophys. Acta 467:208–219.

    PubMed  Google Scholar 

  51. Schlegel, W., Kempner, E. and Rodbell, M. (1979)J. Biol. Chem. 254:5168–5176.

    PubMed  Google Scholar 

  52. Schlegel, W., Cooper, D. M. F. and Rodbell, M. (1980)Arch. Biochem. Biophys. 2011:678–682.

    Google Scholar 

  53. Kempner, E. S. (1993)TIBS 18:236–239.

    PubMed  Google Scholar 

  54. Codina, J., Hildebrandt, J. D., Birnbaumer, L. and Sekura, R. D. (1984)J. Biol. Chem. 259:22408–22418.

    Google Scholar 

  55. Northup, J. K., Sternweiss, P. C. and Gilman, A. G. (1983)J. Biol. Chem. 258:11369–11376.

    PubMed  Google Scholar 

  56. Coulter, S. and Rodbell, M. (1992)Proc. Natl. Acad. Sci. (USA)89:5842–5846.

    Google Scholar 

  57. Sternweis, P. C., Northup, J. K., Smigel, M. D. and Gilman, A. G. (1981)J. Biol. Chem. 256:11517–11527.

    PubMed  Google Scholar 

  58. Jahangeer, S. and Rodbell, M. (1993)Proc. Natl. Acad. Sci. (USA)90:8782–8786.

    Google Scholar 

  59. Nakamura, S. and Rodbell, M. (1990)Proc. Natl. Acad. Sci. (USA)87:6413–6417.

    Google Scholar 

  60. Nakamura, S. and Rodbell, M. (1991)Proc. Natl. Acad. Sci. 88:7150–7154.

    PubMed  Google Scholar 

  61. Tang, W. J. and Gilman, A. G. (1991).Science 254:1500–1503.

    PubMed  Google Scholar 

  62. Rodbell, M., Jahangeer, S. and Coulter, S. (1993) in:GTPases in Biology II (eds Dickey, B. F. and Birnbaumer, L.). Springer-Verlag (Berlin) pp 3–14.

    Google Scholar 

  63. Rodbell, M. (1992)Curr. Top. Cell. Regul. (1992)32:1–47.

    PubMed  Google Scholar 

  64. Carlier, M. F. (1990)Adv. Biophys. 26:51–73.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. 306 Elliott Road, 27514, Chapel Hill, NC, USA

    Martin Rodbell

Authors
  1. Martin Rodbell
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

The Nobel Lecture given on December 8, 1994 by Professor Martin Rodbell and published inLes Prix Nobel 1994, printed by Norstedts Tryckeri, republished here with the permission of the Nobel Foundation, copyright holder.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rodbell, M. Signal transduction: Evolution of an idea. Biosci Rep 15, 117–133 (1995). https://doi.org/10.1007/BF01207453

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01207453

Keywords

Search

Navigation