Summary
Schwann cells are frequently present in retinae of a partially inbred strain of rats, the BW rats. In affected animals, most if not all axons in the nerve fibre layer, immediately adjacent to the optic disc, are ensheathed by Schwann cells. This can occur in the form of a distinct myelin sheath or a simple envelopment of the axons by Schwann cells. Some axons lose their Schwann cell sheath within a few hundred micrometers of the optic discs while others retain the sheath out to the mid-retina. Although the pathophysiological basis of the defect is unknown, it appears to be related to a genetic defect that has widespread C.N.S. expression.
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Blakemore, W. F. (1975) Remyelination by Schwann cells of axons demyelinated by intraspinal injection of 6-aminonicotinamide in the rat.Journal of Neurocytology 4, 745–57.
Büssow, H. (1978) Schwann cell myelination ensheathing C.N.S. axons in the nerve fibre layer of the cat retina.Journal of Neurocytology 7, 207–14.
Collins, G. H. (1966) An electron microscopic study of remyelination in the brainstem of thiamine deficient rats.American Journal of Pathology 48, 259–76.
Coulombre, A. J. &Coulombre, J. L. (1975) Mechanisms of ocular development.International Clinics in Ophthalmology 15, 7–18.
Duke Elder, S. (1964)System of Ophthalmology. Vol. III/2. London: Henry Kempton.
Ghatak, N. R., Hirano, A., Doron, Y. &Zimmerman, H. M. (1973) Remyelination in multiple sclerosis with peripheral type myelin.Archives of Neurology 29, 262–7.
Hogan, M. J., Alvarado, J. A. &Weddell, J. E. (1971)Histology of the Human Eye. An Atlas and Textbook, pp. 393–519. Philadelphia: Saunders.
Jung, H. J., Raine, C. S. &Suzuki, K. (1978) Schwann cells and peripheral nervous system myelin in the rat retina.Acta Neuropathologica 44, 245–7.
Kristensson, K. &Wisniewski, H. M. (1978) Arrest of myelination and demyelination in rabbit retina induced by herpes simplex virus injection.Neuropathology and Applied Neurobiology 4, 71–82.
Peters, A., Palay, S. L. &Webster, H. deF. (1976)The Fine Structure of the Nervous System. Philadelphia: Saunders.
Prince, J. H. (1964) (editor)The Rabbit in Eye Research. Thomas: Springfield, Illinois.
Raine, C. S. (1976) On the occurrence of Schwann cells within the normal central nervous system.Journal of Neurocytology 5, 371–86.
Raine, C. S., Traugott, U. &Stone, S. H. (1978) Glial bridges and Schwann cell migration during chronic demyelination in the C.N.S.Journal of Neurocytology 7, 541–53.
Reynolds, E. S. (1963) The use of lead citrate at high pH as an electron opaque stain in electron microscopy.Journal of Cell Biology 17, 208–12.
Tansley, K. (1956) Comparison of lamina cribrosa in mammalian species with good and with indifferent vision.British Journal of Ophthalmology 40, 178–82.
Tripathi, B. &Ashton, N. (1971) Vasoglial connections in the rabbit retina.British Journal of Ophthalmology 55, 1–11.
Virchow, R. (1856) Zur pathologischen Anatomie der Netzhaut und des Sehnerven.Virchows Archiv für Pathologische Anatomie und Physiologie 10, 170–93.
Wyse, J. P. H. &Hollenberg, M. J. (1977) Complicated colobomatous microphthalmos in the BW rat: A new form of inherited retinal degeneration.American Journal of Anatomy 149, 377–12.
Yanoff, M. &Fine, B. S. (1975)Ocular Pathology: A Text and Atlas, pp. 391–393. Hagerstown, Maryland: Harper and Row.
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Patrick, J., Wyse, H. Schwann cell myelination in the nerve fibre layer of the BW rat retina. J Neurocytol 9, 107–117 (1980). https://doi.org/10.1007/BF01205230
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DOI: https://doi.org/10.1007/BF01205230