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Spektrophotometrische bestimmung von isoniazid mit 2,5-diphenyl-3-thiazolyl-tetrazoliumchlorid in arzneimitteln

Spectrophotometric Determination of Isoniazid in Pharmaceutical Preparations

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Zusammenfassung

Die optimalen Bedingungen für die Reaktion des Isoniazids mit 2,5-Diphenyl-3-thiazolyl-tetrazoliumchlorid (MTT) wurden bestimmt. Auf dieser Grundlage wurde eine genaue und empfindliche spektralphotometrische Bestimmungsmethode ausgearbeitet, deren relativer Fehler 2,0% und deren relative Standardabweichung 4% betragen. Die Empfindlichkeit liegt bei 0,05μg/ml.

Summary

The optimum conditions for the interaction between isoniazid and 2,5-diphenyl-3-thiazolyl tetrazolium chlorid have been investigated. An accurate and sensitive spectrophotometric method (rel. error 2.0%. rel. standard deviation 4%, sensitivity 0.05μg/ml) has been developed.

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Literatur

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Authors and Affiliations

  1. Lehrstuhl für analytische Chemie, Hochschule für Lebensmittelindustrie, Plovdiv, Bulgarien

    E. Kovatscheva, P. Wassileva-Alexandrova & V. Ivanova

Authors
  1. E. Kovatscheva
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  2. P. Wassileva-Alexandrova
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  3. V. Ivanova
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Kovatscheva, E., Wassileva-Alexandrova, P. & Ivanova, V. Spektrophotometrische bestimmung von isoniazid mit 2,5-diphenyl-3-thiazolyl-tetrazoliumchlorid in arzneimitteln. Mikrochim Acta 79, 483–488 (1983). https://doi.org/10.1007/BF01204832

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  • DOI: https://doi.org/10.1007/BF01204832

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