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Lubrithal® (Leo viscous eye gel), precorneal residence time in normal and dry eyes

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Abstract

In an open, right/left controlled study we compared the effects of topical carbomer gel Lubrithal® (Leo viscous eye gel) and polyvinyl alcohol (Liquifilm®, Allergan) in 20 patients with dry eyes and in 20 healthy subjects. The average precorneal residence time of carbomer gel in patients and healthy subjects was 92.8 min (± 35.7) and 36.5 min (± 14.2), respectively, while it was 40.8 min (± 19.4) and 19.5 min (± 8.3) in the polyvinyl alcohol group. The tear break up time was 10 min after instillation significantly longer with the carbomer gel: 23.0 seconds (± 5.5) in dry eye patients and 26.2 seconds (± 4.4) in healthy subjects compared to polyvinyl alcohol: 10.4 seconds (± 3.4) in dry eye patients and 16.5 seconds (± 7.1) in healthy subjects (p < 0.001). Seventy-five per cent of the dry eye patients preferred Lubrithal®.

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Authors and Affiliations

  1. Department of Ophthalmology, College of Medicine, King Saud University, P.O. Box 55307, 11534, Riyadh, Saudi Arabia

    Samir Al-Mansouri & Khalid F. Tabbara

  2. Medical Department, Leo Pharmaceutical Products, Ballerup, Denmark

    Eva Rask-Pedersen

Authors
  1. Samir Al-Mansouri
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  2. Khalid F. Tabbara
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  3. Eva Rask-Pedersen
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Al-Mansouri, S., Tabbara, K.F. & Rask-Pedersen, E. Lubrithal® (Leo viscous eye gel), precorneal residence time in normal and dry eyes. Doc Ophthalmol 88, 187–194 (1994). https://doi.org/10.1007/BF01204617

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  • DOI: https://doi.org/10.1007/BF01204617

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