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The cytological, immunocytochemical and molecular genetic analysis in diagnosis of the neoplasms of the eye, eye adnexa and orbit

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Abstract

The fine needle aspiration biopsy was performed in 91 patients including 57 cases of retrobulbar tumors done under CT control. All aspirates were cytologically examined. In 21 cases immunocytochemical examination was performed in order to distinguish poorly differentiated neoplasms. In 19 cases malignant lymphoma was distinguished from pseudolymphoma. Cytological diagnosis was confirmed by histopathological examination in 77 cases /84%/. One result was false positive, 3-false negative. The value of immunocytochemical methods in differential diagnosis of poorly differentiated neoplasms was stressed.

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References

  1. Bibbo M. Comprehensive cytology in: B. Saunders Company. Philadelphia 1990.

  2. Cavanagh HD, Green WR, Goldberg HK. Multicentric sebaceous adenocarcinoma of the Meibomian gland. Amer J Ophthalmol 1974, 326–332.

  3. Chosia M. Use of immunocytochemical techniques in differential diagnosis of neoplasms in fine needle aspirates. Pomorska Akademia Medyczna. Szczecin Poland 1991.

    Google Scholar 

  4. Cintorino M et al. Expression of actin isoforms and intermediate filament proteins in childhood orbital rhabdomyosarcoma. J Submicrosc Cytol Pathol 1989, 21: 409–419.

    Google Scholar 

  5. Domagala W et al. Differential diagnosis of lymph node aspirates by intermediate filament typing of tumor cells. Acta Cytol 1986, 30: 225–234.

    Google Scholar 

  6. Domagała W et al. Decisive role of intermediate typing oftumor cells in the differential diagnosis of difficult fine needle aspirates. Acta Cytol 1987, 31: 253–266.

    Google Scholar 

  7. Domagala W et al. Immunocytochemical criteria in the differential diagnosis of malignant melanoma versus carcinoma, lymphoma and sarcoma in fine needle aspirates. Pat. Pol. 1991, 42: 73–78.

    Google Scholar 

  8. Dresner Sc, Kennerdell J S, Dekker A. Fine needle aspiration biopsy of metastatic orbital tumors. Surv Ophthalmol 1983, 27: 397–398.

    Google Scholar 

  9. Ellis J H et al. Lymphoid tumors of the ocular adnexa. Ophthalmol 1985, 92: 1311–1324.

    Google Scholar 

  10. Gamel J W, Eiferman R A, Guibor P. Mucoepidermoid carcinoma of the conjunctiva. Arch Ophthalmol Chicago 1984, 102: 73–731.

    Google Scholar 

  11. Gibbs R A. DNA amplification by the polymerase chain reaction. Anal Chem 1990, 62: 1202–1214.

    Google Scholar 

  12. Graham J, Joung S E, Luna M. An unusual case of metastatic carcinoma of the eyelid. Amer J Ophthalmol 1978, 86: 400–402.

    Google Scholar 

  13. Holbach L et al. Zur immunozytochemischen Diagnose embryonaler Rhabdomyosarcome der Orbita. Klin Mbl. Augenheil 1989, 195: 190–195.

    Google Scholar 

  14. Jakobiec F A, Chattock A. Aspiration cytodiagnosis of eyelid tumors. Arch Ophthalmol 1979, 97: 1907–34.

    Google Scholar 

  15. Kennerdell J S et al. Orbital fine needle aspiration biopsy. Amer J Ophthalmol 1985, 99: 547–551.

    Google Scholar 

  16. Koss L G, Woyke S, Olszewski O. Aspiration Biopsy. Cytologic Interpretation and Histologic Bases. Sec ed Iqaku - Shoin, New York, 1992.

    Google Scholar 

  17. Krzystolik Z. Clinical value of fine needle aspiration biopsy and computed tomography in diagnosing pathological changes of the orbit and ocular adnexa. Pomorska Akademia Medyczna. Szczecin - Poland 1989.

    Google Scholar 

  18. Lubiński J, Chosia M, Huebner K. Molecular genetic analysis in the diagnosis of lymphoma in fine needle aspiration biopsies. I. Lymphomas versus benign lymphoproliferative disorders. Anal Quant Cytol Histol 1988, 10: 391–398.

    Google Scholar 

  19. Mansour A M, Hidayat A A. Metastatic eyelid disease. Ophthalmology 1987, 94: 667–670.

    Google Scholar 

  20. Midena E et al. Fine needle aspiration biopsy in ophthalmology. Surv Ophthalmol 1985, 29: 410–422.

    Google Scholar 

  21. Morgan G, Harry J. Lymphatic tumors of interdeterminate nature: a 5 year follow up of 98 conjunctival an orbital lesion. Brit J Ophthalmol 1978, 62: 381–383.

    Google Scholar 

  22. Perlman E, Mc Mahon R L. Sebaceous gland carcinoma of the eyelid. Amer J Ophthal 1978, 86: 699–703.

    Google Scholar 

  23. Shields J A, Shields C L. Orbital Rhabdomyosarcoma. Arch Ophthalmol 1987, 105: 700–701.

    Google Scholar 

  24. Vogiatzis K V. Lymphoid tumors of the orbit and ocular adnexa: A long term follow -up. Ann Ophthalmol 1984, 1046–1055.

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Authors and Affiliations

  1. Department of Ophthalmology, Department of Tumor Pathology, Pomeranian Medical Academy, ul. Staromłyńska 3/2, 70-561, Szczecin, Poland

    Zofia Krzystolik, Anna Rosławska & Elżbieta Bedner

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  1. Zofia Krzystolik
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  2. Anna Rosławska
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  3. Elżbieta Bedner
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Krzystolik, Z., Rosławska, A. & Bedner, E. The cytological, immunocytochemical and molecular genetic analysis in diagnosis of the neoplasms of the eye, eye adnexa and orbit. Doc Ophthalmol 88, 155–163 (1994). https://doi.org/10.1007/BF01204613

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  • DOI: https://doi.org/10.1007/BF01204613

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