Abstract
Fractionized radiation therapy with high-energy electrons have proven to reduce retinal detachment rate from 85% to 5% in the fibroblast model using a dosage of 3000 rad, starting from the first postoperative day. The purpose of this study is to gain more information about the therapeutic range of fractionized radiation therapy in experimental PVR. We therefore investigated the efficacy of this therapy when the total dose is reduced to 2000 rad. Irradiation treatment started on the first postoperative day. Eight weeks after cell implantation 5 of 14 eyes (35%) in the irradiated group and 15 of 16 eyes of the control group (93%) showed traction detachment. The statistically significant result proves a broad therapeutic range of fractionized radiation therapy in experimental PVR. We believe that a combination with antiinflammatory drugs could lead to a dose reduction in both therapies in patients.
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References
Binder S. Klinische und experimentelle Ergebnisse in der Behandlung der massiven periretinalen Proliferation (MPP), der prognostisch ungünstigsten Form der Netzhautabhebung. Wien Klin Wschr 1982; 94(suppl): 1–32.
Lemor M, Yeo JH, Glaser BM. Oral colchicine for the treatment of experimental traction detachment. Arch Ophthalmol 1986; 104: 1226–9.
Tano Y, Chandler D, Machemer R. Treatment of intraocular proliferation with intravitreal injection of triamcinolone acetonide. Am J Ophthalmol 1980; 90: 810–6.
Santana M, Wiedemann P, Kirmani M, Minckler DS, Patterson R, Sorgente N et al. Daunomycin in the treatment of intraocular proliferative vitreoretinopathy: Retinal toxicity of intravitreal daunomycin in the rabbit. Graefes Arch Ophthalmol 1984; 221: 227–31.
Puck TT, Marcus PI. Action of x-rays on mammilian cells. J Exp Med 1956; 103: 653–66.
Stallard HB. The conservative treatment of retinoblastoma. Trans Ophthalmol Soc UK 1962; 82: 473–534.
Brennan MV, Leone CR, Janaki L. Radiation therapy for Graefes disease. Am J Ophthalmol 1983; 96: 195–9.
Binder S, Skorpik Ch, Paroussis P, Kulnig W. High energy electrons used to inhibit experimental intraocular proliferation and detachment. Ophthalmologica 1987; 195: 128–34.
Fastenberg DM, Kenneth RD, Dorey K, Ryan St J. The role of cellular proliferation in an experimental model of massive periretinal proliferation. Am J Ophthalmol 1982; 93: 565–57.
Hatchell DL. Reactive proliferation of host tissue in experimental proliferative vitreoretinopathy. Proc Int Symp on PVR Cologne 1988.
Hitchins CA, Grierson I, Hiscott PS. The effect of injections of cultured fibroblasts into the rabbit vitreous. Graefes Arch Clin Exp Ophthalmol 1985; 223: 237–49.
Velikay M, Binder S, Stolba U, Wedrich A, Datlinger P, Handl-Zeller L. Irradiation pretreatment before fibroblast implantation in experimental PVR. Int Opthalmol (in press).
Körner F, Merz A, Gloor B, Wagner E. Postoperative retinal fibrosis - a controlled clinical study of systemic steroid treatment. Graefes Arch Opthalmol 1982; 219: 268–71.
Wiedemann P, Lemmen K, Schmidl R, Heimann K. Intraocular daunorubicin for the treatment and prophylaxis of traumatic proliferative vitreoretinopathy. Am J Ophthalmol 1987; 104: 10–4.
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Velikay, M., Stolba, U., Wedrich, A. et al. The antiproliferative effect of fractionized radiation therapy: Optimization of dosage. Doc Ophthalmol 87, 265–269 (1994). https://doi.org/10.1007/BF01203855
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DOI: https://doi.org/10.1007/BF01203855