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Endogenous luteinizing hormone surges following administration of human chorionic gonadotropin: Further evidence for lack of loop feedback in humans

  • Reproductive Endocrinology
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Abstract

The existence of inhibitory short- and ultrashort-loop feedback mechanisms for luteinizing hormone (LH), while documented in animals, has been questioned in humans. Since human chorionic gonadotropin (hCG) binds to LH receptors but can be distinguished from LH in immunoassays, it is possible to identify LH surges in the face of exogenously administered hCG. The present study demonstrates LH surges at midcycle in normal volunteers and in women undergoing controlled ovarian hyperstimulation, given hCG. This provides further evidence for lack of loop feedback control of LH secretion in humans.

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Authors and Affiliations

  1. Department of Obstetrics, Gynecology and Reproductive Sciences, University of Texas Medical School, 6431 Fannin, No. 3204, 77030, Houston, Texas, USA

    Shahla Nader & Albert S. Berkowitz

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  1. Shahla Nader
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  2. Albert S. Berkowitz
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Nader, S., Berkowitz, A.S. Endogenous luteinizing hormone surges following administration of human chorionic gonadotropin: Further evidence for lack of loop feedback in humans. J Assist Reprod Genet 9, 124–127 (1992). https://doi.org/10.1007/BF01203751

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  • DOI: https://doi.org/10.1007/BF01203751

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