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Das Rückstandsverhalten des Furazolidonmetaboliten 3-(4-Cyano-2-oxobutylidenamino)-2-oxazolidon in Forellen

The residue behaviour of the furazolidone metabolite 3-(4-Cyano-2-oxobutylideneamino)-2-oxazolidone in trout

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Summary

A high-performance liquid chromatography (HPLC)-method for the determination of furazolidone (FZ) and its open-chain cyano-derivative 3-(4-cyano-2-oxobutylideneamino)-2-oxazolidone (M1) in trout is described. Only during the medication period residues of FZ and M1 were detected in the muscle and liver of the trout, which were treated with food containing FZ over a period of 7 days. After the beginning of the withdrawal period, the concentration of FZ and M1 were found to be under the limits of detection.

Zusammenfassung

Es wird eine HPLC-Methode vorgestellt, die es gestattet, Furazolidon (FZ) neben seinem offenkettigen Cyanometaboliten 3-(4-Cyano-2-oxobutyli-denamino)-2-oxazolidon (M1) in Forellen nachzuweisen. Im Muskel und Leber von Forellen, die 7 Tage lang mit FZ-haltigem Futter behandelt worden waren, konnten nur während der Behandlungszeit Rückstände von M1 und FZ nachgewiesen werden. Schon zu Beginn der Absetzzeit lagen die Konzentrationen an FZ und M1 unterhalb der Nachweisgrenze.

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Literatur

  1. Sugden EA et al. (1983) JAOAC 66:874

    Google Scholar 

  2. Winterlin W (1984) J Environ Sci Health 19:209

    Google Scholar 

  3. Winterlin W et al. (1982) Poultry Sci 61:1113

    Google Scholar 

  4. Petz M (1984) Arch Lebensmittelhyg 35:51

    Google Scholar 

  5. Schmidt Th, Büning-Pfaue H (1985) Dtsch Lebensm Rundsch 81:239

    Google Scholar 

  6. Streeter AJ, Krueger TR, Hoener B-A (1988) Phatmacol 36:283

    Google Scholar 

  7. Loserth J, Schmid A, Mayring L (1988) J Vet Med A 35:207

    Google Scholar 

  8. Swaminathan S, Lower G (1978) In:Carcinogenesis: “Nitrofurans”. Raven Press, New York 4:59

    Google Scholar 

  9. Tatsumi K, Takahashi Y (1982) Chem Pharm Bull 30:3435

    PubMed  Google Scholar 

  10. Nakabeppu H, Tatsumi K (1984) Chem Pharm Bull 32:4193

    PubMed  Google Scholar 

  11. Vroomen LHM (1987) In vivo and in vitro metabolic studies of furazolidone, Thesis, Universität Wageningen

  12. Wölwer-Rieck U, Tomberg W, Büning-Pfaue H (1988) Lebensmittelchem u Gerichtl Chem 42:8

    Google Scholar 

  13. Tatsumi K et al. (1978) J Pharm Dyn 1:256

    Google Scholar 

  14. Schmid A (1985) Tierärztl Praxis 13:471

    Google Scholar 

  15. Vroomen LHM et al. (1986) J Chromatogr 362:141

    PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Professur für Lebensmittelchemie, Universität Bonn, Endenicher Allee 11-13, D-5300, Bonn 1, Bundesrepublik Deutschland

    Ursula Wölwer-Rieck & Hans Büning-Pfaue

Authors
  1. Ursula Wölwer-Rieck
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  2. Hans Büning-Pfaue
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Wölwer-Rieck, U., Büning-Pfaue, H. Das Rückstandsverhalten des Furazolidonmetaboliten 3-(4-Cyano-2-oxobutylidenamino)-2-oxazolidon in Forellen. Z Lebensm Unters Forch 191, 319–321 (1990). https://doi.org/10.1007/BF01202435

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  • DOI: https://doi.org/10.1007/BF01202435

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