Summary
A benign nonchromaffin paraganglioma of the duodenum is described and compared with other reported cases. Duodenal location is extremely rare but the morphology, based on the optical microscopic pattern (Zellballen) and the ultrastructural appearance is, comparable with paragangliomas of other sites. The lack of nerve fibres and ganglion cells in this tumour, together with the absence of a positive chromaffin reaction permits us to classify it as a pure nonchromaffin paraganglioma. This finding constitutes indirect evidence of the probable existence of a paraganglion in the duodenal wall, a structure not yet demonstrated in the adult.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Coupland, R.E.: The natural history of the chromaffin cell. London: Longman, Green & Co., Ltd. 1965
Costero, I., Barroso-Moguel, R.: Structure of carotid body tumors. Am. J. Pathol.38, 127–141 (1961)
Dahl, E.U., Waugh, I.M., Dahlin, D.C.: Gastrointestinal ganglioneuromas: Brief review with report of a duodenal ganglioneuroma. Am. J. Pathol.33, 953–965 (1957)
Fernandez, B.B., Hernandez, F.J., Staley, Ch.J.: Chemodectoma of the vagus nerve. Report of a case with ultrastructural study. Cancer35, 263–269 (1975)
Gemer, M., Feuchtwanger, M.M.: Ganglioneuroma of the duodenum. Gastroenterology51, 689–693 (1966)
Glenner, G.G., Grimley, P.M.: Tumors of the extraadrenal paraganglion system (including chemoreceptors). In: Atlas of Tumor Pathology, second series, fascicle 9. Washington, D.C.: Armed Forces Institute of Pathology 1974
Goldman, R.L.: Ganglioneuroma of the duodenum: Relationship to nonchromaffin paraganglioma of the duodenum. Am. J. Surg.115, 716–719 (1968)
Goormaghtigh, N.: On the existence of abdominal vagal paraganglia in the adult mouse. J. Anat.71, 77–90 (1936)
Helpap, B.: Extraadrenale Paraganglien und Paragangliome. In: Normal and Pathological Anatomy, Bargmann, W. and Doerr, W. (eds.), Vol. 37. Stuttgart: Georg Thieme 1978
Kepes, J.J., Zacharias, D.L.: Gangliocytic paragangliomas of the duodenum. A report of two cases with light and electron microscopic examination. Cancer27, 61–70 (1971)
Lauzon, A., Cadotte, M.: Paragangliome gangliocytaire du duodenum. Union Med. Can.101, 1584–1586 (1972)
Lukash, W.M., Hyams, U.J., Nielsen, O.F.: Neurogenic neoplasms of the small bowel. Benign nonchromaffin paraganglioma of the duodenum. Report of a case. Am. J. Dig. Dis.11, 575–579 (1966)
Moncure, A.C., Goodman, M.L.: Cervical mass with hoarseness and anemia in a young man. Case record of the Massachusetts General Hospital. New Engl. J. Med.292, 741–745 (1975)
Qizilbash, A.H.: Benign paraganglioma of the duodenum. Arch. Pathol.96, 276–280 (1973)
Reed, R.J., Daroca, Jr., P.J., Harkin, J.C.: Gangliocytic paraganglioma. Am. J. Surg. Pathol.1, 207–216 (1977)
Someren, A., Karcioglu, Z.: Malignant vagal paraganglioma. Report of a case and review of literature. Am. J. Clin. Pathol.68, 400–408 (1977)
Taylor, H.B., Helwig, E.B.: Benign nonchromaffin paragangliomas of the duodenum. Virchows Arch. Path. Anat.335, 356–366 (1962)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Matilla, A., Rivera, F., Fernández-Sanz, J. et al. Nonchromaffin paraganglioma of the duodenum. Virchows Arch. A Path. Anat. and Histol. 383, 217–223 (1979). https://doi.org/10.1007/BF01200901
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01200901