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Über die „malabsorptive“ Dermatitis herpetiformis Duhring

Eine katamnestische Studie unter besonderer Berücksichtigung dünndarm-bioptischer Befunde

“Malabsorptive” Dermatitis herpetiformis Duhring

A study with particular regard to biopsy findings of the small intestine

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Summary

21 patients (6 females and 15 males) with Dermatitis herpetiformis have been studied with special considerations of the small intestinal biopsyfindings. During this investigation the patient's mean age was 45 years (20–68) and the mean age at onset was 38 years (17–64).

In 5 patients (23.8%) total villous atrophy (group I) and in 4 patients (19.0%) a severe partial or subtotal villous trophy (group II) was found on small intestinal biopsy. The sprue-like changes were patchy lesions. Histocompatibility-antigens of type HLA-A1 were found in 38.1% and of type HLA-B8 in 47.6%. After 20 years of the disease one patient died of a malignant lymphoma of the intestine (immunoblastic sarcoma).

In all patients the number of interepithelial lymphocytes in the small bowel mucose was significantly increased, as it was in those patients with a normal villous pattern (group III). In a quantitative analysis of specifically labeled (peroxidase-anti-peroxidase complex) IgG-, IgA- and IgM-cells in the intestinal mucosa it was found that the number of all three plasma cell classes are increased significantly (P<0.01).

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Authors and Affiliations

  1. Pathologisches Institut, Allergieabteilung der Hautklinik und 1. Medizinische Klinik der Universität Hamburg, D-2000, Hamburg 20, Bundesrepublik Deutschland

    H. F. Otto, J. Sack, J. -O. Gebbers, K. -H. Schulz & K. Müller-Wieland

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  1. H. F. Otto
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  2. J. Sack
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  3. J. -O. Gebbers
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  4. K. -H. Schulz
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  5. K. Müller-Wieland
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Additional information

Herrn Professor Dr. med. W. Doerr zum 65. Geburtstag

Mit Unterstützung durch die Deutsche Forschungsgemeinschaft

Teile dieser Arbeit haben als Dissertation dem Fachbereich Medizin der Universität Hamburg vorgelegen

Fräulein C. Schürmann danken wir für die gute technische Assistenz bei der Anfertigung der histologischen und immunhistologischen Schnittpräparate.

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Otto, H.F., Sack, J., Gebbers, J.O. et al. Über die „malabsorptive“ Dermatitis herpetiformis Duhring. Virchows Arch. A Path. Anat. and Histol. 383, 195–206 (1979). https://doi.org/10.1007/BF01200899

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