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Regression of atherosclerosis in primates

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References

  • Adams, C.W.M., Morgan, R.S., Bayliss, O.B.: No regression of atheroma over one year in rabbits previously fed a cholesterol-enriched diet. Atherosclerosis18, 429–444 (1973)

    PubMed  Google Scholar 

  • Anitschkow, N.N.: Über die Rückbildungsvorgänge bei der experimentellen Atherosklerose. Verh. dtsch. path. Ges.23, 473–478. Zentralbl. Allg. Path. path. Anat., Suppl. to Vol. 43 (1928)

    Google Scholar 

  • Anitschkow, N.N.: A history of experimentation on arterial atherosclerosis in animals. In: Cowdry's arteriosclerosis: A survey of the problem, Blumenthal, H.T. (ed.), p. 32. Springfield: Charles C. Thomas 1967

    Google Scholar 

  • Armstrong, M.L.: Regression of Atherosclerosis. Atherosclerosis Rev.1, 137–182 (1976)

    Google Scholar 

  • Armstrong, M.L.: Connective tissue in regression. Atherosclerosis Rev.3, 147–168 (1978)

    Google Scholar 

  • Armstrong, M.L., Megan, M.B.: Lipid depletion in atheromatous coronary arteries in rhesus monkeys after regression diets. Circ. Res.30, 675–680 (1972)

    PubMed  Google Scholar 

  • Armstrong, M.L., Megan, M.B.: Arterial fibrous proteins in cynomolgus monkeys after atherogenic and regression diets. Circ. Res.36, 256–261 (1975)

    PubMed  Google Scholar 

  • Armstrong, M.L., Warner, E.D., Connor, W.E.: Regression of coronary atheromatosis in rhesus monkeys. Circ. Res.27, 59–67 (1970)

    PubMed  Google Scholar 

  • Augustyn, J.M., Fritz, K.E., Daoud, A.S., Jarmolych, J., Lee, K.T.: Biochemical effects of moderate diet and clofibrate on swine atherosclerosis. Arch. Path. Lab. Med.102, 294–297 (1978)

    PubMed  Google Scholar 

  • Berger, F.M., Douglas, J.F., Ludwig, B.J., Margolin, S.: The effect of W-1372 on experimental atherosclerosis and hypercholesterolemia. J. Pharmacol. Exp. Ther.170, 371–381 (1969)

    PubMed  Google Scholar 

  • Bevan, R.D., Marthens, E.V., Bevan, J.A.: Hyperplasia of vascular smooth muscle in experimental hypertension in the rabbit. Circ. Res.38 (Suppl. II), 58–62 (1976)

    PubMed  Google Scholar 

  • Blankenhorn, D.H.: Reversibility of latent atherosclerosis. Studies by femoral angiography in humans. Mod. Conc. Cardiovasc. Dis.47, 79–84 (1978)

    Google Scholar 

  • Bond, M.G., Bullock, B.C., Lehner, N.D.M., Clarkson, T.B.: Regression of atherosclerosis at plasma cholesterol concentrations achievable in man. In: Atherosclerosis IV., Schettler, G. et al. (eds.), pp. 278–280. Berlin: Springer 1977

    Google Scholar 

  • Bretherton, K.N., Day, A.J., Skinner, S.L.: The effect of renal hypertension on the regional deposition of cholesterol and phospholipid in the aorta of normally and cholesterol-fed rabbits. Atherosclerosis22, 517–532 (1975)

    PubMed  Google Scholar 

  • Constantinides, P., Booth, J., Carlson, G.: Production of advanced cholesterol atherosclerosis in the rabbit. Arch. Path70, 712–724 (1960)

    PubMed  Google Scholar 

  • Crawford, D.W., Blankenhorn, D.H.: Quantitative studies of atherosclerotic plaque size in human subjects. In: State of prevention and therapy in human arteriosclerosis and in animal models, W.H. Hauss et al. (eds.), Abh. der Rhein.-Westf. Akademie der Wissenschaften 63, pp. 55–68. Opladen: Westdeutscher Verlag 1978

    Google Scholar 

  • DePalma, R.G., Insull, W., Bellon, E.M., Roth, W.T., Robinson, A.V.: Animal models for the study of progression and regression of atherosclerosis. Surgery72, 268–278 (1972)

    PubMed  Google Scholar 

  • Devices and Technology Branch, Division of Heart and Vascular Diseases, National Heart, Lung, and Blood Institute: 1978 Contractors Conference Program. Washington: U.S. Dept. of Health, Education and Welfare 1978

    Google Scholar 

  • Eggen, D.A., Strong, J.P., Newman, W.P., Catsulis, C., Malcom, G.T., Kokatnur, M.G.: Regression of diet-induced fatty streaks in rhesus monkeys. Lab. Invest.31, 294–301 (1974)

    PubMed  Google Scholar 

  • Evans, T.C., Jr., Green, P.S., Greenleaf, J.F.: Development of high-resolution ultrasonic imaging techniques for detection and clinical assessment of cardiovascular disease. Report NO1-HV-4-2904-4, National Institutes of Health. Springfield, Virginia: National Technical Information Service 1978

    Google Scholar 

  • Gresham, G.A.: Primate atherosclerosis. Monogr. Atheroscler., Vol. 7. Basel: Karger 1976

    Google Scholar 

  • Hauss, W.H., Wissler, R.W., Lehmann, R. (eds.): State of Prevention and Therapy in Human Arteriosclerosis and in Animal Models. Abh. der Rhein.-Westf. Akademie der Wissenschaften 63. Opladen: Westdeutscher Verlag 1978

    Google Scholar 

  • Hess, H.: Regression of atherosclerosis in man. In: Atherosclerosis — is it reversible? Schettler, G. et al. (eds.), pp. 89–92. Berlin: Springer 1978

    Google Scholar 

  • Hollander, W., Madoff, I., Paddock, J., Kirkpatrick, B.: Aggrevation of atherosclerosis by hypertension in a subhuman primate model with coarctation of the aorta. Circ. Res.38 (Suppl. II), 63–72 (1976)

    PubMed  Google Scholar 

  • Jarmolych, J., Daoud, A.S., Fritz, K.E., Augustyn, J.M., Singh, J.K., Kim, D.N.: Morphological effects of moderate diet and clofibrate on swine atherosclerosis. Arch. Path. Lab. Med.102, 289–293 (1978)

    PubMed  Google Scholar 

  • Kannel, W.B., Schwartz, M.J., McNamara, P.M.: Blood pressure and risk of coronary heart disease: The Framingham study. Dis. Chest56, 43–52 (1969)

    PubMed  Google Scholar 

  • Kokatnur, M.G., Malcom, G.T., Eggen, D.A., Strong, J.P.: Depletion of aortic free and ester cholesterol by dietary means in rhesus monkeys with fatty streaks. Atherosclerosis21, 195–203 (1975)

    PubMed  Google Scholar 

  • Lehner, N.D.M., Greene, A.W.: Indirect measurement of blood pressure in nonhuman primates. In: Proceedings of a workshop on blood pressure measurement in hypertensive animal models, pp. 71–80. Washington: U.S. Dept. of Health, Education and Welfare 1978

    Google Scholar 

  • Leren, P., Hjermann, I.: Attempts at primary and secondary prevention of coronary heart disease. In: Atherosclerosis IV, Schettler, G. etal. (eds.), pp. 680–686. Berlin: Springer 1977

    Google Scholar 

  • Malinow, M.R., McLaughlin, P., McNulty, W.P., Naito, H.K., Lewis, L.A.: Treatment of established atherosclerosis during cholesterol feeding in monkeys. Atherosclerosis31, 185–193 (1978a)

    PubMed  Google Scholar 

  • Malinow, M.R., McLaughlin, P., Naito, H.K., Lewis, L.A., McNulty, W.P.: Effect of alfalfa meal on shrinkage (regression) of atherosclerotic plaques during cholesterol feeding in monkeys. Atherosclerosis30, 27–43 (1978b)

    PubMed  Google Scholar 

  • Mann, G.V., Andrus, S.B.: Xanthomatosis and atherosclerosis produced by diet in an adult rhesus monkey. J. Lab. Clin. Med.48, 533–550 (1956)

    PubMed  Google Scholar 

  • Maruffo, C.A., Portman, O.W.: Nutritional control of coronary artery atherosclerosis in the squirrel monkey. J. Atherosclerosis Res.8. 237–247 (1968)

    Google Scholar 

  • McMillan, G.C., Stary, H.C.: Preliminary experience with mitotic activity of cellular elements in the atherosclerotic plaques of cholesterol-fed rabbits studied by labeling with tritiated thymidine. An. N.Y. Acad. Sci.149, 699–709, 1968

    Google Scholar 

  • Olinger, C.P., Nigam, A.K.: Development and evaluation of instrument systems for non-invasive detection, characterization and quantification of atherosclerotic lesions. Report NO1-HV-7-2924-1, National Institutes of Health. Springfield, Virginia: National Technical Information Service 1978

    Google Scholar 

  • Pick, R., Glick, G.: Effect's of propranolol, minoxidil, and clofibrate on cholesterol-induced atherosclerosis in stumptail macaques (Macaca arctoides). Atherosclerosis27, 71–77 (1977)

    PubMed  Google Scholar 

  • Pick, R., Johnson, P.J., Glick, G.: Deleterious effect's of hypertension on the development of aortic and coronary atherosclerosis in stumptail macaques (Macaca speciosa) on an atherogenic diet. Circ. Res.35, 472–482 (1974)

    PubMed  Google Scholar 

  • Pick, R., Prabhu, R., Glick, G.: Diet-induced atherosclerosis and experimental hypertension in stumptail macaques. Effects of antihypertensive drugs and a non-atherogenic diet in the evolution of lesions. Atherosclerosis29, 405–429 (1978)

    PubMed  Google Scholar 

  • Portman, O.W., Alexander, M., Maruffo, C.A.: Nutritional control of arterial lipid composition in squirrel monkeys: Major ester classes and types of phospholipids. J. Nutrition91, 35–46 (1967)

    Google Scholar 

  • Prathap, K.: The natural history of platelet-rich mural thrombi in systemic arteries of hypercholesterolaemic monkeys: light- and electron-microscope observations. J. Path.110, 203–212 (1973)

    PubMed  Google Scholar 

  • Prior, J.T., Ziegler, D.D.: Regression of experimental atherosclerosis. Arch. Path.80, 50–57 (1965)

    Google Scholar 

  • Robertson, W.B., Strong, J.P.: Atherosclerosis in persons with hypertension and diabetes mellitus. Lab. Invest.18, 538–551 (1968)

    PubMed  Google Scholar 

  • Samuels, A.I., Mitchell, D.S., Peel, H.H., McGill, H.C., Jr.: The measurement of blood pressure in baboons. In: Proceedings of a workshop on blood pressure measurement in hypertensive animal models, pp. 65–70. Washington: U.S. Dept. of Health, Education, and Welfare 1978

    Google Scholar 

  • Schettler, G., Stange, E., Wissler, R.W. (eds.): Atherosclerosis — is it reversible? Berlin: Springer 1978

    Google Scholar 

  • Schmitt, G., Knoche, H., Junge-Hülsing, Koch, R, Hauss, W.H.: Über die Reduplikation von Aortenwandzellen bei arterieller Hypertonie. Z. Kreislaufforsch.59, 481–487 (1970)

    PubMed  Google Scholar 

  • Stary, H.C.: Proliferation of arterial cells in atherosclerosis. Adv. Exp. Med. Biol. 43, 59–81. New York: Plenum Press 1974a

    Google Scholar 

  • Stary, H.C.: Cell proliferation and ultrastructural changes in regressing atherosclerotic lesions after reduction of serum cholesterol. In: Atherosclerosis III, Schettler, G., Weizel, A. (eds.), pp. 187–190. Berlin: Springer 1974b

    Google Scholar 

  • Stary, H.C.: Ultrastructural changes in the lipid inclusions of arterial smooth muscle cells after reduction of high serum cholesterol levels. Prog. Biochem. Pharmacol. 13, 46–51. Basel: Karger 1977

    Google Scholar 

  • Stary, H.C.: The origin in atherosclerotic lesions of extracellular lipid and debris and their elimination during regression. In: State of prevention and therapy in human arteriosclerosis and in animal models, Hauss, W.H. et al. (eds.), Abh. der Rhein.-Westf. Akademie der Wissenschaften 63, 39–53. Opladen: Westdeutscher Verlag 1978

    Google Scholar 

  • Stary, H.C., Eggen, D.A., Strong, J.P.: The mechanism of atherosclerosis regression. In: Atherosclerosis IV, Schettler, G., et al. (eds.), pp. 394–404. Berlin: Springer 1977

    Google Scholar 

  • Stary, H.C., Eggen, D.A., Strong, J.P.: Ultrastructural evidence of atherosclerosis regression after reduction of serum cholesterol from high to moderate levels. Fed. Proc.37, 934 (1978)

    Google Scholar 

  • Strong, J.P., Eggen, D.A., Stary, H.C.: Reversibility of fatty streaks in rhesus monkeys. Primates in Medicine9, 300–320 (1976)

    PubMed  Google Scholar 

  • Strong, J.P. (ed.): Atherosclerosis in primates. Primates in medicine, Vol. 9. Basel: Karger 1976

    Google Scholar 

  • Taylor, C.B., Cox, G.E., Manalo-Estrella, P., et al.: Atherosclerosis in rhesus monkeys: II. Arterial lesions associated with hypercholesterolemia induced by dietary fat and cholesterol. Arch. Path.74, 16–34 (1962)

    PubMed  Google Scholar 

  • The Coronary Drug Project Research Group: Clofibrate and niacin in coronary heart disease. J. Am. Med. Ass.231, 360–381 (1975).

    Google Scholar 

  • Vesselinovitch, D., Wissler, R.W., Hughes, R., Borensztajn, J.: Reversal of advanced atherosclerosis in rhesus monkeys. Part 1. Light-microscopic studies. Atherosclerosis23, 155–176 (1976)

    Google Scholar 

  • Vesselinovitch, D., Wissler, R.W., Schaffner, T., Hughes, R., Borensztajn, J.: Reversal of advanced atherosclerosis in rhesus monkeys by prudent diet with and without cholestyramine. Circulation56 (Suppl. III), 144 (1977)

    Google Scholar 

  • Vesselinovitch, D., Wissler, R.W., Borensztajn, J., Schaffner, T.: The effect of diets with or without cholestyramine on the lesion components of atherosclerotic plaques. Fed. Proc.37. 835 (1978)

    Google Scholar 

  • Wagner, W.D., St. Clair, R.W., Clarkson, T.B.: Atherosclerosis regression in rhesus monkeys at plasma cholesterol levels achievable in man. Fed. Proc.35, 293 (1976)

    Google Scholar 

  • Wissler, R.W.: Current status of regression studies. Atherosclerosis Rev.3, 213–229 (1978)

    Google Scholar 

  • Wissler, R.W., Vesselinovitch, D.: Atherosclerosis in nonhuman primates. Adv. Vet. Sc. Comp. Med.21, 351–420 (1977)

    Google Scholar 

  • Wissler, R.W., Vesselinovitch. D., Borensztajn, J., Hughes, R.: Regression of severe atherosclerosis in cholestyramine-treated rhesus monkeys with or without a low-fat, low-cholesterol diet. Circulation52 (Suppl. II), 16 (1975)

    PubMed  Google Scholar 

  • Wolinsky, H.: Effects of hypertension and its reversal on the thoracic aorta of male and female rats. Circulation Res.28, 622–637 (1971)

    PubMed  Google Scholar 

  • Wolinsky, H., Goldfischer, S., Daly, M.M., Kasak, L.E., Coltoff-Schiller, B.: Arterial lysosomes and connective tissue in primate atherosclerosis and hypertension. Circulation Res.36, 553–561 (1975)

    PubMed  Google Scholar 

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Stary, H.C. Regression of atherosclerosis in primates. Virchows Arch. A Path. Anat. and Histol. 383, 117–134 (1979). https://doi.org/10.1007/BF01200894

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