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Crystal and molecular structure of chloramphenicol

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Abstract

Chloramphenicol, C11H12Cl2N2O5, is orthorhombic, space groupC2221,a = 17.495(3),b = 7.321(2),c = 22.130(4) Å, andZ = 8. The structure was solved by direct methods and refined to a finalR value of 0.068 for 1186 counter-reflections. Estimated standard deviations for bond lengths and bond angles involving nonhydrogen atoms average 0.009 Å and 0.6 °, respectively. All the hydrogen atoms that are bonded to O or N and are available for hydrogen-bond formation take part in the hydrogen-bonding network. The crystals become brown in color on prolonged exposure to X-rays and γ-rays. Our structural investigation with colored crystal does not indicate any structural change.

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Authors and Affiliations

  1. Crystallography and Molecular Biology Division, Saha Institute of Nuclear Physics, 700 009, Calcutta, India

    C. Chatterjee, J. K. Dattagupta & N. N. Saha

  2. Abt. Chemie, Max Plank Institut fur Experimentelle Medizin, D-3400, Gotingen, B. R. D.

    W. Saenger & K. Müller

Authors
  1. C. Chatterjee
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  2. J. K. Dattagupta
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  3. N. N. Saha
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  4. W. Saenger
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  5. K. Müller
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Chatterjee, C., Dattagupta, J.K., Saha, N.N. et al. Crystal and molecular structure of chloramphenicol. Journal of Crystal and Molecular Structure 9, 295–304 (1979). https://doi.org/10.1007/BF01200521

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  • DOI: https://doi.org/10.1007/BF01200521

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