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Crystal structure and spectroscopic study of 2-[(2,6-dichlorophenyl)amino]phenylacetoxyacetic acid (Aceclofenac)

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Abstract

The crystal structure of the title compound has been determined. The crystals are monoclinic:P21 n(NO. 14),a=12.279(7),b=8.223(1),c=15.504(7)Å,β=96.16(2)°,V c =1556(2)Å3,Z=4,D x =1.511 g cm−3,λ=(MoKα)=0.71069 Å. The structure was solved by direct methods and refined with 1970 reflections to a finalR value of 0.057. Analytical, mass, spectral, and physicochemical data are also reported.

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References

  • Ballesteros, R., Ansoleaga, J. J., and Tapounet, R. (1990) Clin. Tri. J.27(1), 12–19.

    Google Scholar 

  • Cecchettin, M., Cerea, P., and Torri, G. (1988)Clin. Tri. J. 25(2), 144–151.

    Google Scholar 

  • Dearden, J. C. (1985)Environ. Health Persp. 61, 203–228.

    Google Scholar 

  • Diaz, C., Rodriguez, A., Geli, C., Llobet, J. M. and Tapounet, R. (1988)Curr. Ther. Res. 44(2), 252–256.

    Google Scholar 

  • Grau, M., Montero, J. L., Guasch, J., Felipe, A., Carrasco, E., and Juliá, S. (1991)Drugs in Inflammation, Vol. 32. M. J. Parnham, M. A. Bray, and W. B. Van den Berg, (Birkhäuser Verlag Basel).

    Google Scholar 

  • International Tables for X-Ray Crystallography (1974) Vol. IV (Kynoch Press, Birmingham) (Present Distributor D. Reidel, Dordrecht).

  • Lipka, A. (1978)Z. Anorg. Allg. Chem. 440, 224–230.

    Google Scholar 

  • Lipka, A. (1980)Z. Anorg. Allg. Chem. 466, 195–202.

    Google Scholar 

  • Motherwell, S., and Clegg, W. (1978)Pluto (University Chemical Laboratory, Cambridge, England).

    Google Scholar 

  • Moser, P., Sallmann, A., and Wiesenberg, I. (1990)J. Med. Chem. 33, 2358–2368.

    Google Scholar 

  • Movilia, P. G. (1989)Drugs Exp. Clin. Res. 15(1), 47–51.

    Google Scholar 

  • Reck, G., Faust, G., and Dietz, G. (1988)Pharmazie 43, 771–774.

    Google Scholar 

  • Rihs, G. (1991) Private communication (Ciba-Geigy AG, Basel, Switzerland).

    Google Scholar 

  • Sheldrick, G. M. (1976)Shelx 76. Program for crystal structure determination (Univ. of Cambridge, England).

    Google Scholar 

  • Sheldrick, G. M. (1985).Shelxs 86. InCrystallographic Computing 3, G. M. Sheldrick, C. Krüger, and R. Goddard, eds. (Oxford Univ. Press), pp. 175–189.

  • Skoutakis, V. A., Carter, C. A., Mickle, T. R., Smith, V. H., Arkin, C. R., Alissandros, J., and Petty D. A. (1988)Drug Intelligence Clin. Pharm. 22, 850–859.

    Google Scholar 

  • Vila Casas, A. (1984).Eur. Pat. 119932.

  • Wang, P. H., and Lien E. J. (1980)J. Pharm. Sci. 69, 662–668.

    Google Scholar 

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Authors and Affiliations

  1. Area de Cristallografia, Universitat Autónoma de Barcelona, 08193, Bellaterra, Spain

    A. Alvarez-Larena & J. F. Piniella

  2. Prodesfarma, Centro de Investigación, C/Trabajo s/n, 08960, Sant Just Desvern (Barcelona), Spain

    E. Carrasco, A. Ginebreda & S. Julia

  3. Unité de Chimie-Physique Moléculaire et de Cristallographie, Université de Louvain 1, Place Louis Pasteur, B-1348, Louvain-La-Neuve, Belgium

    G. Germain

Authors
  1. A. Alvarez-Larena
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  2. J. F. Piniella
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  3. E. Carrasco
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  4. A. Ginebreda
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  5. S. Julia
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  6. G. Germain
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Alvarez-Larena, A., Piniella, J.F., Carrasco, E. et al. Crystal structure and spectroscopic study of 2-[(2,6-dichlorophenyl)amino]phenylacetoxyacetic acid (Aceclofenac). Journal of Crystallographic and Spectroscopic Research 22, 323–328 (1992). https://doi.org/10.1007/BF01199535

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  • DOI: https://doi.org/10.1007/BF01199535

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