Abstract
Norfloxacin, a nalidixic acid analog with antimicrobial properties, exists in different hydrated forms. Three of these crystal forms were reproducibly prepared and characterized by analytical techniques that included infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, differential scanning calorimetry, solution microcalorimetry and pulsed nuclear-magnetic resonance spectroscopy.
These studies showed that the dihydrate is the thermodynamically stable entity at ambient temperatures and humidities.
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Katdare, A.V., Ryan, J.A., Bavitz, J.F. et al. Characterization of hydrates of norfloxacin. Mikrochim Acta 90, 1–12 (1986). https://doi.org/10.1007/BF01196816
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DOI: https://doi.org/10.1007/BF01196816