Abstract
The content of norepinephrine (NE) and serotonin (5-HT) in the right and left halves of the brain of rats was compared in the norm, during the development of defensive two-way avoidance conditioned reflexes (TWACR), and with the administration of peptides which influence learning and memory, namely desglycine-arginine vasopressin (DG-AVP), ACTH4-7 pro-gly-pro, and dalargin. These investigations demonstrated that the content of NE in the right cerebral hemisphere is significantly higher than in the cortex of the left. Significant differences — were not detected with respect to the 5-HT content in symmetrical parts of the brain. The asymmetry of the NE content was eliminated under the influence of the development of the TWACR. The systemic administration of DG-AVP, ACTH4–7 proglypro, and dalargin essentially did not alter the 5-HT content, and decreased the NE content in the cortex and in the rest of the brain. In the process the NE content of the right and left hemisphere evened out. The data obtained point to the asymmetrical character of the action of the neuropeptides and to the greater resistance of the serotoninergic system of the brain to a functional load and the administration of peptides by comparison with the noradrenergic system.
Similar content being viewed by others
Literature cited
V. L. Bianki,The Asymmetry of the Brain of Animals [in Russian], Nauka, Leningrad (1985).
N. N. Bragina and T. A. Dobrokhotova,The Functional Asymmetry of Man [in Russian], Meditsina, Moscow (1988).
R. Yu. H'yuchenok, A. L. Finkel'berg, I. R. Il'yuchenok, and L. I. Aftanas,The Interaction of the Cerebral Hemispheres in Man: Set, Information Processing, Memory [in Russian], Nauka, Novosibirsk (1989).
É. A. Kostandov,The Functional Asymmetry of the Cerebral Hemispheres and Nonconscious Perception [in Russian], Nauka, Moscow (1983).
V. K. Lutsenko and M. Yu. Karganov, “The biochemical asymmetry of the brain,”Neirokhimiya,4, No. 2, 197–213 (1985).
M. Pappai, K. Hecht, M. Hilsey, A. Mareira-Aquino, L. Pichet, and P. Aimé, “The significance of the asymmetrical distribution of norepinephrine in the brain and adrenals for the development of experimental neurosis,” in:Investigations of the Mechanisms of Experimental Neurosis [in Russian], Nauka, Moscow (1984), pp. 280–283.
S. Springer and G. Deitsch,Left Brain, Right Brain [Russsian translation], Mir, Moscow (1983).
E. I. Chazov, N. P. Bekhtereva, G. Ya. Vakalinin, and G. A. Vartanyan, “Chemical asymmetry of the brain,”Nauka v SSSR, No. 1, 21–29 (1987).
R. K. Dismukes and A. V. Rake, “Involvement of biogenic amines in memory formation,”Psychopharmacologia,23, 17–25 (1972).
S. D. Click, D.A. Ross, and L. B. Hough, “Lateral asymmetry of neurotransmitters m human brain,”Brain Res.,234, 53–63 (1982).
R. P. Maikel, R. H. Cox, Jr., J. Saillant, and F. P. Miller,J. Neuropharmacol.,7, 275–287 (1968).
A. Ohe, R. Lewis, and R. N. Adams, “Hemispheric asymmetry of norepinephrine in rat thalamus,”Brain Res.,188, No. 2, 269 (1980).
Author information
Authors and Affiliations
Additional information
Translated from Zhurnal Vysshei Nervnoi Deyatel'nosti imeni I. P. Pavlova, Vol. 41, No. 2, pp. 359–363, March–April, 1991.
Rights and permissions
About this article
Cite this article
Kruglikov, R.I., Orlova, N.V. & Getsova, V.M. Content of norepinephrine and serotonin in symmetrical divisions of the brain of rats in the norm during learning and with the administration of peptides. Neurosci Behav Physiol 22, 128–131 (1992). https://doi.org/10.1007/BF01192384
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF01192384