Abstract
The role of brain-specific nonhistone Np-3.5 proteins of chromatin in the processes of the reproduction of a developed defense habit in response to food was studied in preliminarily trained edible snails. It was found that gamma globulins to Np-3.5 over the course of tens of minutes suppress behavioral and neuronal reactions elicited by a specific conditional stimulus, carrot juice, while not altering the reaction to a different conditional stimulus, apple juice. The gamma globulins to other nonhistone proteins of chromatin did not exert an influence on the reproduction of habits of food rejection. It is hypothesized that brain-specific nonhistone Np-3.5 proteins of chromatin are selectively involved in the molecular processes supporting the neurophysiological mechanisms of the extraction of information from long-term memory.
Similar content being viewed by others
Literature cited
I. P. Ashmarin and S. A. Titov, “Contemporary notions of the mechanisms of neurological memory,”Biol. Nauki, No. 3, 30–42 (1988).
A. A. Karavanov and B. N. Afanas'ev, “The nonhistone proteins of chromatin,”Molekulyar. Biologiya,17, No. 2, 213–233 (1983).
R. I. Kniglikov, “Principal lines of research of the neurochemical mechanisms of learning and memory,”Zhurn. Vyssh. Nervn. Deyat.,36, No. 2, 226–231 (1986).
A. Leninger,Principles of Biochemistry, Vol. 1 [Russsian translation], Mir, Moscow (1985).
O. A. Maksimov and P. M. Balaban,Neuronal Mechanisms of the Plasticity of Behavior [in Russian], Nauka, Moscow (1983).
A. A. Mekhtiev, M. A. Gruden', and A. B. Poletaev, “The identification and isolation of glycoproteins and nuclear proteins of the bovine brain,”Biokhimiya,49, No. 12, 1959–1964 (1984).
E. N. Sokolov, “Endoneuronal mechanisms of reinforcement,”Zhurn. Vyssh. Nervn. Deyat.,37, No. 3, 403–407 (1987).
V. V. Sherstnev, S. A. Kozyrev, and V. P. Nikitin, “Brain-specific regulatory proteins of chromatin in the organization of the functional system of the defense behavior of molluscs,” in:Summaries of Reports of the International Symposium “Integrative Activity of the Neuron: Molecular Bases” [in Russian], Moscow (1988), p. 136.
H. P. Davis and L. R. Squire, “Protein synthesis and memory,”Psychol. Bull,96, No. 3, 518–558 (1984).
W. J. Davis, J. Villet, D. Lee, M. Rigler, R. Gillette, and E. Prince, “Selective and differential avoidance learning in the feeding and withdrawal behaviora ofPleurobranchaea,”J. Comp. Physiol.,138, No. 1, 157–165 (1980).
A. Gelperin, J. J. Hopfiel, and D. W. Tank, “The logic of Limax learning,” in:Model Neural Networks and Behaviour, Vol. 24, Plenum Press, New York (1985), pp. 237–261.
M. U. Gillette, J. A. London, and R. Gillette, “Motivation to feed affects acquisition of food avoidance conditioning inPleurobranchaea,”Soc. Neurosci. Abstr.,9, 914 (1984).
P. Goelet, V. F. Castellucci, S. Schacher, and E. R. Kandel, “The long and short of long-term memory — a molecular framework,”Nature,322, No. 6078, 419–422 (1986).
W. L. Klein, J. Sullivan, A. Skorupa, and S. J. Agular, “Plasticity of neural receptors,”FASEB J.,3, No. 10, 2132–2140 (1989).
T. Makoto, N. S. Imamoto, and T. Uchida, “Monoclonal antibody against non-histone chromosomal protein high mobility group 1 co-migrates with high mobility group 1 into nucleus,”J. Biol. Chem.,261, No. 2, 1829–1834 (1986).
H. Polet, “Effects of fibroblastic growth factor on protein degradation in the migration of non-histone protein to the nucleus and DNA synthesis in diploid fibroblasts,”Exptl. Cell Res.,169, No. 1, 178–190 (1987).
I. Serra and S. Giuffrida, “DNA-associated protein modifications involved in the regulation of gene expression in brain,”Ital. J. Biochem.,35, No. 2, 104A-116A (1987).
A. Susswein, M. Schwarz, and E. Feldman, “Learned changes in feeding behaviora inAplysia in response to edible and inedible foods,”J. Neurosci. 6, No. 5, 1513–1527 (1986).
J. G. Sutcliffe, “mRNA in the mammalian central nervous system,”Ann. Rev. Neurosci.,11, 157–198 (1988).
Author information
Authors and Affiliations
Additional information
Translated from Zhurnal Vysshei Nervnoi Deyatel'nosti imeni I. P. Pavlova, Vol. 41, No. 2, pp. 323–332, March–April, 1991.
Rights and permissions
About this article
Cite this article
Kozyrev, S.A., Nikitin, V.P. & Sherstnev, V.V. Selective participation of brain-specific nonhistone Np-3.5 proteins of chromatin in the processes of the reproduction of a defensive habit in response to food in edible snails. Neurosci Behav Physiol 22, 120–127 (1992). https://doi.org/10.1007/BF01192383
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF01192383