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Intracentral interstructural relationships in the process of kindling electrostimulations of the hippocampus

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Abstract

The features of the development of hippocampal kindling as a function of intracentral interstructural relationships formed during electrostimulations has been studied in 13 rabbits by means of electrodes chronically implanted in the brain (cerebral cortex, hippocampi, amygdalar nuclei, rostral portions of the caudate nuclei). The interstructural relationships were evaluated on the basis of the expressivity of the epileptic activity in various structures of the brain and on the basis of its dependence on the activity in the primary pathological focus. It was shown that in the case of the formation in the primary hippocampal epileptic focus of the pathological determinant (as described by G. N. Kryzhanovskii), which determine the activity of other structures, the kindling syndrome develops rapidly. If, on the other hand, competitive suppressive influences predominate in the interrelationships between the primary and secondary epileptic foci, which was most strikingly manifested between the hippocampal epileptic foci, then the pathological determinant does not form in this region and the kindling syndrome does not develop.

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Literature cited

  1. Yu. G. Grigor'ev and O. A. Timofeeva, “Two types of chronic epileptogenesis in rabbits during kindling stimulation of the hippocampus,”Byul. Éksp. Biologii i Meditsiny,97, No. 1, 1316 (1984).

    Google Scholar 

  2. G. N. Kryzhanovskii,Determinant Structures in the Pathology of the Nervous System [in Russian], Meditsina, Moscow (1980).

    Google Scholar 

  3. V. M. Okudzhava, “The nature of epileptic neurons,”Zhurn. Nevropatol. i Psikhiatr.,72, No. 2, 168–171 (1972).

    Google Scholar 

  4. O. A. Timofeeva, “Spontaneous interstructural spikes in rabbits subjected to kindling electrostimulation of the hippocampus,”Byul. Éksp. Biologii i Meditsiny,96, No. 10, 5–8 (1983).

    Google Scholar 

  5. J. L. Burchfiel, K. A. Sepra, and F. H. Duffy, “Further studies of antagonism of seizure development between concurrently developing kindled limbic foci in the rat,”Exp. Neurol.,75, No. 2, 476–489 (1982).

    PubMed  Google Scholar 

  6. D. P. Cain and M. E. Corcoran, “Kindling with low-frequency stimulation: generality, transfer and recruiting effects,”Exptl Neurol.,73, No. 1, 219–232 (1981).

    Google Scholar 

  7. M. S. Dochowny and J. L. Burchdiel, “Facilitation and antagonism of kindled seizure development in the limbic of the rat,”EEG and Clin. Neurophysiol.,51, No. 4, 403–416 (1971).

    Google Scholar 

  8. J. Engel, Jr. and R. T. Ackermann, “Interictal EEG spikes correlate with decreased rather than with increased epilepto-genicity in amygdaloid kindled rats,”Brain Res.,190, No. 2, 543–548 (1980).

    PubMed  Google Scholar 

  9. J. G. Fitz and J. O. McNamara, “Spontaneous interictal spiking in the awake kindled rat,”EEG and Clin. Neurophysiol.,47, No. 5, 592–596 (1979).

    Google Scholar 

  10. G. V. Goddard, D. C. McIntyre, and C. J. Leech, “A permanent change in brain function resulting from daily electrical stimulations,”Exp. Neurol.,25, No. 3, 295–330 (1969).

    PubMed  Google Scholar 

  11. E. M. Kairiss, R. J. Racine, and G. K. Smith, “The development of the interictal spike during kindling in the rat,”Brain Res.,322, No. 1, 101–110 (1984).

    PubMed  Google Scholar 

  12. M. Sato and M. Takashi, “Postictal seizure inhibition in amygdaloid kindled rats,”Epilepsia,25, No. 5, 545–550 (1984).

    PubMed  Google Scholar 

  13. L. J. R. Racine, “Modification of seizure activity by electrical stimulation,”EEG and Clin. Neurophysiol.,32, No. 2, 269–279 (1972).

    Google Scholar 

  14. J. A. Wada and M. Sato, “The generalized convulsive seizure states induced by daily electrical stimulation of the amygdala in split brain cats,”Epilepsia,16, No. 3, 417–430 (1975).

    PubMed  Google Scholar 

  15. J. A. Wada, M. Sato, and M. E. Corcoran, “Persistent seizure susceptibility and recurrent spontaneous seizures in kindled cats,”Epilepsia,15, No. 4, 465–478 (1974).

    PubMed  Google Scholar 

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  1. Moscow

    O. A. Timofeeva

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  1. O. A. Timofeeva
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Translated from Fiziologicheskii Zhurnal SSSR imeni I. M. Sechenova, Vol. 76, No. 4, pp. 430–437, April, 1990.

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Timofeeva, O.A. Intracentral interstructural relationships in the process of kindling electrostimulations of the hippocampus. Neurosci Behav Physiol 21, 353–358 (1991). https://doi.org/10.1007/BF01191579

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  • DOI: https://doi.org/10.1007/BF01191579

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