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Effects of corticotropin on the thymus and the hypothalamo-pituitary-adrenal system

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Conclusion

  1. 1.

    Intramuscular administration of ALG to guinea pigs at a dose of 5 mg/kg/day for 10 days induces the development of thymomegaly.

  2. 2.

    Thymomegaly is accompanied by overproduction of STH and PL in the adenohypophysis, stimulation of lymphopoiesis (through T-lymphocytes), and depression of glucocorticoid function of the adrenals as a result of reduced ACTH secretion.

  3. 3.

    In thymomegaly induced by ALG, the content of DA, NE, and serotonin in the hypothalamus increases.

  4. 4.

    Zn-ACTH in a dose of 1 U/kg/day for 5–10 days is sufficient for attaining thymic involution.

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Literature cited

  1. A. E. Gorbalenya, A. V. Shul'ga, Yu. I. Videlets, et al., Probl. Éndokrinol., No. 4, 90–93 (1977).

    Google Scholar 

  2. T. F. Dogherty et al., Prog. Hematol.,3, 155 (1962).

    Google Scholar 

  3. V. F. Chebotarev, Endocrine Regulation of Immunogenesis [in Russian], Kiev (1979).

  4. D. Metcalf, Cancer Res.,20, 1347 (1960).

    Google Scholar 

  5. P. Deschaux, J. Physiol. (Paris),76, 357–371 (1980).

    Google Scholar 

  6. P. Deschaux, Thymus,1, 95–108 (1979).

    Google Scholar 

  7. A. Maneva and V. Manev, Sovrem. Med. (Bulg.),31, (7), 373–377 (1980).

    Google Scholar 

  8. A. White and A. L. Coldstein, Adv. Metab. Disord.,8, 359–374 (1975).

    Google Scholar 

  9. H. Besedovcky and E. Sorkin, Clin. Exp. Immunol.,27, 1–12 (1977).

    Google Scholar 

  10. B. N. Manukhin, L. V. Berdysheva, and E. V. Volina, Vopr. Med. Khim., No. 3, 317 (1975).

    Google Scholar 

  11. M. Kurts, I. Nad', and P. Baronyats, Probl. Éndokrinol., No. 5, 65–71 (1969).

    Google Scholar 

  12. Yu. A. Pankov and I. Ya. Usvatova, in: Methods in the Clinical Biochemistry of Hormones and Mediators [in Russian], Moscow (1969), pp. 37–40.

  13. J. C. Andersson and S. Nordling, J. Immunol.,114, 1226 (1975).

    Google Scholar 

  14. M. Jondall, G. Holm, and L. Wigre, J. Exp. Med.,136, 207–215 (1972).

    Google Scholar 

  15. M. J. Stadecker, J. Immunol.,111, 1834 (1973).

    Google Scholar 

  16. L. Mal'ea, Kh. V. Dias, and A. Gonsales-Grego, Labor. Delo, No. 1, 7–8 (1979).

    Google Scholar 

  17. P. F. Rokitskii, Biological Statistics [in Russian], Minsk (1973).

  18. W. Pierpaoli and E. Sorkin, Nature,215, 834 (1967).

    Google Scholar 

  19. J. Bierich, et al., Mtschr. Kinderheilk.,115, 310 (1967).

    Google Scholar 

  20. Yu. A. Umanskii, Immunological Reactivity in Cancer [in Russian], Kiev (1974), p. 192.

  21. D. Trevor et al., Brain Res.,202, 335–345 (1980).

    Google Scholar 

  22. T. Oishi, Endocrinol. Jpn.,26, 399–408 (1979).

    Google Scholar 

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Authors and Affiliations

  1. A. I. Karaev Institute of Physiology, Academy of Sciences of the Azerbaijan SSR, USSR

    Sh. G. Guseinov, M. G. Aliev & T. G. Kurbanov

  2. A. M. Aliev Azerbaijan Institute of Postgraduate Medicine, Baku

    Sh. G. Guseinov, M. G. Aliev & T. G. Kurbanov

Authors
  1. Sh. G. Guseinov
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  2. M. G. Aliev
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  3. T. G. Kurbanov
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Translated from Problemy Endokrinologii, Vol. 28, No. 3, pp. 51–55, May–June, 1982.

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Guseinov, S.G., Aliev, M.G. & Kurbanov, T.G. Effects of corticotropin on the thymus and the hypothalamo-pituitary-adrenal system. Neurosci Behav Physiol 13, 135–138 (1983). https://doi.org/10.1007/BF01190798

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  • DOI: https://doi.org/10.1007/BF01190798

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