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Effectiveness of Soviet-produced human somatotropin in the treatment of hypothalamo-pituitary dwarfism

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Conclusion

  1. 1.

    The Soviet human STH preparation is an effective pathogenetic growth stimulant in HPD with endogenous STH insufficiency.

  2. 2.

    After 12 months of treatment with STH the gain in height of HPD patients was 8.28 ±O.32 cm, and 15.6 ±O.6 cm after 24 months.

  3. 3.

    The mean gain in height after one month was 1.28 cm, 0.76 cm/month during the next nine months, and then 0.49 cm/month until the 24th month.

  4. 4.

    A slower gain in height is obtained with intermittent treatment than with a continuous regimen; however, in the former case sensitivity to the hormone is retained for a much longer period of time.

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Authors and Affiliations

  1. Laboratory of the Chemistry and Mechanism of Action of Hormones, USSR

    D. G. Lashene

  2. Kaunas Branch of the Institute of Experimental Endocrinology and Hormone Chemistry, USSR

    D. G. Lashene

  3. Academy of Medical Sciences of the USSR, Moscow

    D. G. Lashene

Authors
  1. D. G. Lashene
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Translated from Problemy Éndokrinologii, Vol. 28, No. 3, pp. 39–43, May–June, 1982.

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Lashene, D.G. Effectiveness of Soviet-produced human somatotropin in the treatment of hypothalamo-pituitary dwarfism. Neurosci Behav Physiol 13, 126–129 (1983). https://doi.org/10.1007/BF01190796

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  • DOI: https://doi.org/10.1007/BF01190796

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