Summary
The RNP group reported here is involved in tissue- and species-specific stimulation of template activity of chromatinin vitro. Template activity of calf thymus chromatin can be enhanced by the RNP isolated from calf thymus up to 300 %. Against this RNP group species- and tissue-specific antibodies can be produced. These antibodies cause a species- and tissue-specific inhibition of the transcription. Antibodies against chromatin and non-histone protein-DNA complex from chick's oviduct produced by Chytil and Spelsberg [6] show a cross reaction with RNP's isolated from chick's oviduct in the Ouchterlony test.
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Dedicated to Prof. Dr. Dr. h. c. mult. B. Rajewsky on the occasion of his 80th birthday.
This work was supported by the Ministerium für Bildung und Wissenschaft of the Federal Republic of Germany.
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Wilhelm, G., Sellier, J.L. A ribonucleoprotein group with species- and tissue-specific biological activity. Biophysik 10, 257–265 (1973). https://doi.org/10.1007/BF01190585
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DOI: https://doi.org/10.1007/BF01190585