Abstract
We have studied the effect of a reduction in the serotonin level at different times in the prepubertal period on the neuroendocrine and morphometric characteristics of sexual maturation of male rats. We established that injection of p-chlorophenylalanine, a blocker of serotonin synthesis, into male rats on the 30th and 34th day of life leads to activation of the endocrine function of the testes in 60-day-old animals. Injection of the preparation at later times, 40th and 44th day, produced a marked inhibiting effect on sexual maturation, expressed as inhibition of both the spermatogenic and the endocrine function of the testes of the animals investigated. The data obtained allow an assessment of the dual role of serotonin in the regulation of the rate of sexual maturation of male rats at different prepubertal periods.
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Literature cited
E. V. Naumenko, A. V. Osadchuk, L. I. Serova, and G. T. Shishkina, Genetic-Physiological Mechanisms of Regulation of the Endocrine Function of Testes [in Russian], Nauka, Novosibirsk (1983), p. 202.
E. I. Plekhova, “Role of monoamines in the pathogenesis of disorders of sexual maturation,” Prob. Endokrinol.,32, No. 2, 51–54 (1986).
G. T. Shishkina and P. M. Borodin, “Rate of sexual maturation of tame and aggressive grey rats,” Fiziol. Zh. SSSR,72, No. 7, 992–996 (1986).
G. Benetato, M. Uluitu, and G. Suhaciu, “Serotonin variations in the rat hypothalamus and rhinencephalon in terms of age,” Rev. Roum. Physiol.,4, No. 2, 107–113 (1967).
P. S. Brown, “Pituitary FSH in immature female rats treated with drugs that inhibit or antagonize the actions of catecholamines or 5-HT,” Neuroendocrinology,7, 183–192 (1971).
R. Collu, J. C. Jéquier, J. Letarte, G. Leboeuf, and J. R. Ducharme, “Endocrine effects of brain serotonin depletion by 5,6-dihydroxytryptamine in prepubertal male rats,” Neuroendocrinology,14, No. 2, 139–150 (1974).
A. Corbin and B. A. Schottelius, “Hypothalamic neurohormonal agents and sexual maturation of immature female rats,” Am. J. Physiol.,201, No. 9, 1176–1180 (1961).
D. Emery, J. Engel, and K. Larsson, “Rat strain differences in brain monoamine metabolism following para-chlorophenylalanine treatment,” Pharmacol. Biochem. Behav.,12, No. 2, 311–312 (1980).
D. M. Jacobowitz and J. C. Richardson, “Method for the rapid determination of norepinephrine, dopamine, and serotonin in the same brain region,” Pharmacol. Biochem. Behav.,8, No. 4, 515–519 (1978).
G. A. Kinson and C. C. Liu, “Testicular responses to melatonin and serotonin implanted peripherally in immature rats,” Life Sci.,12, 173–184 (1973).
B. K. Koe and A. Weissman, “The pharmacology of p-chlorophenylalanine, a selective depletor of serotonin stores,” in: Advances in Pharmacology, editors S. Garattini and P. Shaw, Vol. 6, Pt. B, Acad. Press, New York-London (1968), pp. 29–47.
J. A. Moguilevsky, M. R. Faigon, P. Scacohi, and B. Szwarfarb, “Effect of the serotonergic system on luteinizing hormone secretion in prepubertal female rats,” Neuroendocrinology,40, No. 2, 135–138 (1985).
D. A. Peters, M. Filczewski, and J. M. Mazurkiewicz-Kwilecki, “Effect of para-chloro-phenylalanine on catecholamine synthesis in the rat brain, heart, adrenals,” Biochem. Pharmacol.,2, No. 11, 2282–2284 (1972).
P. Stark, R. W. Fuller, L. W. Hartley, R. J. Schaffer, and J. A. Turk, “Dissociation of the effects of p-chlorophenylalanine on self-stimulation and on brain serotonin,” Life Sci.,9, pt. 1, 41–48 (1970).
W. K. O'Steen, “Suppression of ovarian activity in immature rats by serotonin,” Endocrinology,77, No. 7, 937–939 (1965).
R. Tonjes, W. Kitzrow, J. Poppe, and G. Dorner, “Possible role played by monoatnines in the control of puberty onset in female rats,” Exp. Clin. Endocrinol.,83, No. 1, 1–5 (1984).
A. G. Watts and H. F. Stanley, “Indolamines in the hypothalamus and area of the mid-brain raffe nuclei of male and female rats throughout postnatal development,” Neuro-endocrinology,38, No. 4, 461–466 (1984).
C. A. Wilson, M. Andrews, J. C. Hadley, M. Lemon, and T. Yeo, “The role of hypothalamic serotonin (5-HT) before ovulation in immature rats treated with pregnant mare serum (PMS),” Psychoneuroendocrinology,2, No. 2, 267–274 (1977).
C. A. Wilson, A. S. McNeilly, and T. Yeo, “Mechanisms by which 5-HT stimulates ovulation in the immature rat treated with pregnant mare serum gonadotropin,” Acta Endocrinol.,111, No. 2, 235–240 (1986).
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Translated from Fiziologicheskii Zhurnal SSSR imeni I. M. Sechenova, Vol. 74, No. 1, pp. 118–123, January, 1988.
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Shishkina, G.T., Borodin, P.M. Involvement of brain serotonin in regulation of sexual maturity in male rats. Neurosci Behav Physiol 19, 145–149 (1989). https://doi.org/10.1007/BF01190460
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DOI: https://doi.org/10.1007/BF01190460