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Effect of steroid hormones on the template activity of DNA and glucocorticoid-receptor interaction

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Conclusions

  1. 1.

    The inhibiting effect of steroid hormones on the incorporation of [3H]uridine into the acid-insoluble fraction of thymocyte RNA decreases in the sequence cortisol > progesterone > pregnanediol > aldosterone > pregnenolone > 11-DHC > cortexolone > methyltestosterone > cortisone > 17α-OH-progesterone > androsterone > estradiol > aldactone > testosterone > pregnanetriol.

  2. 2.

    The competition of steroid hormones with [3H]triamcinolone acetonide for binding to the glucocorticoid receptor of the thymocyte cytosol decreases in the series progesterone > 11-DHC > cortisol > pregnanediol > aldosterone > cortexolone > cortexolone acetate > 17α-OH-progesterone > methyltestosterone > testosterone > pregnenolone > estradiol > cortisone.

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Authors and Affiliations

  1. Clinico-Biochemical Laboratory of Special Methods of Investigation, N. V. Sklifosovskii Scientific-Research Institute of First Aid, Ministry of Health of the RSFSR, Moscow

    P. P. Golikov & A. S. Bobkova

Authors
  1. P. P. Golikov
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  2. A. S. Bobkova
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Translated from Problemy Éndokrinologii, Vol. 27, No. 3, pp. 52–56, May–June, 1981.

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Golikov, P.P., Bobkova, A.S. Effect of steroid hormones on the template activity of DNA and glucocorticoid-receptor interaction. Neurosci Behav Physiol 12, 385–388 (1982). https://doi.org/10.1007/BF01189300

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  • DOI: https://doi.org/10.1007/BF01189300

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