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The influence of high-frequency stimulation of the midbrain reticular formation on the interaction of neurons of the neocortex

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Abstract

The influence of the stimulation of the midbrain reticular formation (NRT) at a frequency of 75–100 Hz, current strength 33–400 μA, on the interaction of neurons of the visual and sensorimotor areas of the neocortex of rabbits was investigated. Cross- and autocorrelation histograms of the impulse sequences were plotted. Stimulation of the NRT led to an increase in the number of pairs of neurons functioning in correlation and an increase in the probability of discharges of neurons one after the other with delays from 100 to 400 msec as compared with resting wakefulness. The mechanisms of the interaction of the cells were not altered in the process. Comparison with previously obtained data made it possible to conclude that activation of the NRT may lead to specific changes in the interaction of neurons which are observable during pseudoconditioning and at the beginning of the development of a conditioned reflex.

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References

  1. O. G. Baklavadzhyan and V. S. Eganova, “The neuronal mechanisms of hypothalamo-reticular influences on the activity of the cerebral cortex,”Uspekhi Fiziol. Nauk,13, No. 2, 3–30 (1982).

    Google Scholar 

  2. N. Yu. Belenkov, “The conditioned reflex and the reticular formation,” in:The Structural-Functional Bases of Conditioned Reflexes. Materials of a Symposium [in Russian], Nauka, Leningrad (1970), pp. 18–35.

    Google Scholar 

  3. N. V. Bobkova, “The influence of coagulation of nuclei of the reticular formation (NRP and NRT) on the level of spatial synchronization of the biopotentials of the neocortex of the rabbit,” Zh.Vyssh. Nerv. Deyat.,29, No. 4, 831–839 (1979).

    Google Scholar 

  4. P. V. Bukh-Viner, I, V. Volkov, and G. Kh. Merzhanova, “The spike collector,”Zh. Vyssh. Nerv. Deyat.,40, No. 6, 1194–1199 (1990).

    Google Scholar 

  5. G. G. Gasanov, Z. G. Mamedov, and N. F. Samedova, “Change in the reactivity of neurons of the visual cortex under the influence of the posterolateral hypothalamus and the nuclei of the midbrain raphé,”Fiziol. Zh. SSSR,74, No. 5, 617–624 (1988).

    Google Scholar 

  6. V. I. Zadorozhnyi, “The reorganization of the mosaic of the activity of neurons of the sensorimotor cortex in rabbits under the influence of nonspecific afferentation,”Zh. Vyssh. Nerv. Deyat.,32, No. 5, 970–972 (1982).

    Google Scholar 

  7. L. V. Kalyuzhnyi and I. N. Zakharova, “EEG data on the interrelationships of the visual area of the cortex, the hypothalamus, the hippocampus, and the midbrain reticular formation during the formation of a temporary connection,” in:The Physiology and Pathophysiology of the Limbicoreticular System [in Russian], Nauka, Moscow (1971), pp. 35–40.

    Google Scholar 

  8. I. N. Knipst, “The spatial synchronization of bioelectrical oscillations of the cortex and some subcortical structures of the rabbit brain during the development of conditioned reflexes,” in:Contemporary Problems in the Electrophysiology of the Central Nervous System [in Russian], Nauka, Moscow (1967), pp. 127–137.

    Google Scholar 

  9. M. N. Livanov, “The mechanism of the activating effect of the reticular formation on the cerebral cortex,”Dokl. Akad. Nauk SSSR,224, No. 6, 1460–1463 (1975).

    Google Scholar 

  10. M. N. Livanov, “The functional significance of some subcortical structures,”Uspekhi Fiziol. Nauk,12, No. 3, 3–21 (1981).

    Google Scholar 

  11. I. V. Pavlova, “The coupling of the impulse activity of neurons of the visual and sensorimotor areas of the neocortex of rabbits in resting wakefulness and pseudoconditioning,”Zh. Vyssh. Nerv. Deyal.,37, No. 5, 850–859 (1987).

    Google Scholar 

  12. I. V. Pavlova,The Interaction of Neurons of the New Cortex in Tonic Conditioned Reflexes [in Russian], Nauka, Moscow (1990).

    Google Scholar 

  13. I. V. Pavlova and V. A. Zosimovskii, “The interaction of neurons of the visual and sensorimotor areas of the neocortex during the development and the extinction of the conditioned defense reflex,”Zh. Vyssh. Nerv. Deyat.,34, No. 4, 710–718 (1984).

    Google Scholar 

  14. I. V. Pavlova and V. A. Zosimovskii, “The types of correlational relationships of the impulse activity of neurons of the visual and sensorimotor areas of the neocortex in rabbits,”Zh. Vyssh. Nerv. Deyat.,37, No. 2, 313–322 (1987).

    Google Scholar 

  15. I. S. Stashkevich and N. V. Veber, “The character of the functional connections of neurons of the sensorimotor cortex in the case of isolated and combined stimulations of the thalamic nuclei,”Zh. Vysh. Nerv. Deyat.,29, No. 4, 823–830 (1979).

    Google Scholar 

  16. V. D. Trush, T. A. Korol'kova, L. V. Tishaninova, et al., “The functional significance and principles of organization of the spatial synchronization of background biopotentials of the cerebral cortex,” in:The Spatial Synchronization of Brain Biopotentials [in Russian], Nauka, Moscow (1973), pp. 28–66.

    Google Scholar 

  17. Zh. P. Shuranova and Z. M. Gvozdikova, “The neuronal mechanisms of reticulocortical activation,”Zh. Vyssh. Nerv. Deyat.,31, No. 1, 129–140 (1981).

    Google Scholar 

  18. L. P. Yakupova,The Spatial-Temporal Organization of the Impulse Activity of Neurons of a Microarea of the Visual Cortex of the Rabbit in the Presence of Specific and Nonspecific Stimulation [in Russian], IVND i NF AN SSSR, Moscow (1987).

    Google Scholar 

  19. Z. A. Yanson, “The influence of the mesencephalic reticular formation on the spatial synchronization of brain biopotentials,”Zh. Vyssh. Nerv. Deyat.,23, No. 1, 159–165 (1973).

    Google Scholar 

  20. E. Fifkova and J. Maršala, “Stereotaxic atlas for the cat, rabbit and rat,” in:Electrophysiological Methods in Biological Research, Prague (1960), pp. 426–468.

  21. V. M. Kumar, M. Mariotti, M. Schieppati, D. Esposti, and M. Mancia, “Postsynaptic changes in sensorimotor cortical neurons during brain stem reticular activation,”Brain Res.,163, No. 1, 156–160 (1979).

    Google Scholar 

  22. G. P. Moore, Y. P. Segundo, D. H. Perkel, and H. Levitan, “Statistical sings [sic] of synaptic interaction in neurons,”Biophys. J.,10, No. 9, 876–900 (1970).

    Google Scholar 

  23. G. Moruzzi and H. W. Magoun, “Brain stem reticular formation and activation of the EEG,”EEG a. Clin. Neurophysiol.,1, No. 3, 445–475 (1949).

    Google Scholar 

  24. D. H. Perkel, G. L. Gerstein, and G. P. Moore, “Neuronal spike trains and stochastic point processes,”Biophys.,7, No. 4, 391–440 (1967).

    Google Scholar 

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Authors and Affiliations

  1. Institute of Higher Nervous Activity and Neurophysiology, USSR Academy of Sciences, Moscow

    I. V. Pavlova

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  1. I. V. Pavlova
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Translated from Zhurnal Vysshei Nervnoi Deyatel'nosti imeni I. P. Pavlova, Vol.41, No.6, pp.1177–1185, November–December, 1991.

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Pavlova, I.V. The influence of high-frequency stimulation of the midbrain reticular formation on the interaction of neurons of the neocortex. Neurosci Behav Physiol 23, 152–159 (1993). https://doi.org/10.1007/BF01189112

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  • DOI: https://doi.org/10.1007/BF01189112

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