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Chorionic gonadotropin as a modulator of cell interactions in the induction of a primary immune response

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Conclusions

  1. 1.

    At low (40 a.u.) but not high (200 a.u.) doses CG stimulates the formation of APC during the primary immune response to the thymus-dependent antigen.

  2. 2.

    Administration of CG inhibits the capacity of B-lymphocytes for cooperative interactions with T-cells.

  3. 3.

    Administration of the hormone to T-cell donors has no effect on the ability of the latter to enter into cooperative interactions with intact B-lymphocytes in the body of syngeneic, lethally irradiated recipients.

  4. 4.

    CG exerts a dose-dependent stimulating action on the cooperative processes in irradiated syngeneic recipients. The 40-a.u. dose produces a more pronounced stimulating effect than the 200-a.u. dose.

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Authors and Affiliations

  1. Department of Biochemistry of the Perm Medical Institute, USSR

    N. N. Kevorkov & S. V. Shirshev

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  1. N. N. Kevorkov
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  2. S. V. Shirshev
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Translated from Problemy Endokrinologii, Vol. 33, No. 2, pp. 60–62, March–April, 1987.

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Kevorkov, N.N., Shirshev, S.V. Chorionic gonadotropin as a modulator of cell interactions in the induction of a primary immune response. Neurosci Behav Physiol 17, 448–451 (1987). https://doi.org/10.1007/BF01188737

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  • DOI: https://doi.org/10.1007/BF01188737

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