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Involvement of transplanted neurons of rat embryonic neocortex in host's neocortical sensory functions

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Conclusions

  1. 1.

    Transplants of embryonic neocortex survive successfully in the neocortical zone of the vibrissa projection inadult rats.

  2. 2.

    The transplanted neurons show background activity with a character and average frequency which are no different from those of the background activity of intact cortex and which depend upon the degree of wakefulness of the animal.

  3. 3.

    The character of the responses to vibrissa deflection, the latent periods of the responses, and the lability of the responses does not differ from normal. However, the receptive fields of the transplanted neurons are significantly wider than those in the intact zone of vibrissa representation.

  4. 4.

    The data obtained indicate the possibility of functional integration of transplanted neocortical tissue and participation of such tissue in the analysis of specific types of somatic information.

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Authors and Affiliations

  1. Institute of Biochemical Physics, Academy of Sciences of the USSR, Pushchino

    A. G. Bragin

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Translated from Zhurnal Vysshei Nervnoi Deyatel'nosti imeni I. P. Pavlova, Vol. 36, No. 5, pp. 930–938, September–October, 1987.

The authors express their appreciation to O. S. Vinogradova for valuable advice during discussions of the material and during the preparation of the article.

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Bragin, A.G. Involvement of transplanted neurons of rat embryonic neocortex in host's neocortical sensory functions. Neurosci Behav Physiol 17, 427–434 (1987). https://doi.org/10.1007/BF01188733

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  • DOI: https://doi.org/10.1007/BF01188733

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