Conclusions
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1.
Early visual deprivation has an inhibitory effect on activity of mediator receptor interaction, studied in relation to binding of serotonin and tryptamine by synaptosomes of structures of the visual system of the rabbit brain.
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2.
Restoration of visual function leads to normalization of the activity of this process.
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3.
The regular correlation observed between visual impulsation and activity of mediator-receptor interaction suggests that serotonin plays a specific and, evidently, neuromediator role in the visual system.
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4.
The lower degree of recovery of the ability of synaptosomes of the visual system to interact with tryptamine compared with serotonin suggests that tryptaminergic receptors possess different subsites for binding these two indoleamines.
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Literature cited
A. A. Volokhov and Z. D. Pigareva, Zh. Vyssh. Nerv. Deyat.,25, No. 4, 799 (1975).
A. A. Volokhov and N. N. Shilyagina, Zh. Vyssh. Nerv. Deyat.,22, No. 4, 735 (1972).
E. L. Dovedova, in: Functional and Structural Bases of the Activity of Brain Systems and Mechanisms of Brain Plasticity [in Russian], No. 3, Brain Institute, Moscow (1974), p. 397.
Z. D. Pigareva, Usp. Sovr. Biol.,79, No. 1, 48 (1975).
M. G. Uzbekov, Proceedings of a Conference on the Structure and Function of the Nervous System [in Russian], Brain Institute, Moscow (1972), p. 46.
M. G. Uzbekov, Lab. Delo, No. 4, 211 (1974).
F. G. Uzbekov, T. M. Ivanova, and Kh. G. Bernshtain, in: Functional and Structural Bases of Activity of Brain Systems and Mechanisms of Brain Plasticity [in Russian], No. 3, Brain Institute, Moscow (1974), p. 171.
M. G. Uzbekov and Z. D. Pigareva, Proceedings of an All-Union Conference on the Physiology and Biochemistry of Mediator Processes [in Russian], Moscow (1976), p. 130.
S. G. A. Alivisatos, F. Ungar, P. K. Seth, L. P. Levitt, A. J. Gerouslis, and T. S. Meyers, Science,171, 809 (1971).
M. J. Berridge and W. T. Prince, Nature New Biol.,243, 283 (1973).
P. O. Bishop, G. Field, B. L. Hennessy, and J. R. Smith, J. Neurophysiol.,21, 529 (1958).
C. Blakemore and G. Cooper, Nature,228, 477 (1970).
D. R. Curtis and R. Davis, Brit. J. Pharmacol.,18, 217 (1962).
E. V. Evarts, W. Landau, W. Freygang, and W. H. Marshall, Am. J. Physiol.,182, 594 (1955).
G. F. Fairclough and J. S. Fruton, Biochemistry,5, 673 (1966).
P. Grobstein, K. L. Chow, and P. C. Fox, Proc. Nat. Acad. Sci. USA,72, 1543 (1975).
H. V. B. Hirsch and D. N. Spinelli, Exp. Brain Res.,12, 509 (1971).
D. H. Hubel and T. H. Wiesel, J. Physiol. (London),209, 419 (1970).
O. H. Lowry, N. J. Rosebrough, A. L. Farr, and R. J. Randall, J. Biol. Chem.,193, 265 (1951).
E. de Robertis, A. P. Iraldi, G. R. L. Arnaiz, and L. Salganicoff, J. Neurochem.,9, 23 (1962).
S. P. R. Rose and A. K. Sinha, Life Sci.,15, 223 (1974).
J. Szentagothai and J. Hamori, in: Cellular Dynamics of the Neuron, edited by S. H. Barondes, New York (1969), p. 301.
F. Valverde, Brain Res.,33, 1 (1971).
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Translated from Zhurnal Vysshei Nervnoi Deyatel'nosti, Vol. 26, No. 6, pp. 1291–1295, November–December, 1976.
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Uzbekov, M.G. Role of visual impulsation in the development of receptor properties of synaptosomal membranes with age. Neurosci Behav Physiol 8, 117–120 (1977). https://doi.org/10.1007/BF01186940
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DOI: https://doi.org/10.1007/BF01186940