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Identification and characterization of the binding properties of steroid hormone receptors in the nuclear fraction of adenomas of the human prostate gland

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Conclusions

  1. 1.

    Specific binding of 5α-DHT, corresponding to the androgen receptors according to the value of the measurable Kα and hormonal specificity of affinity, was detected in 0.4 M KC1 extracts of human prostate adenoma nuclei.

  2. 2.

    Specific binding of progesterone, corresponding in its characteristics to the progestin receptors, was detected in the same material.

  3. 3.

    A very low level of specific binding of estradiol is detected in nuclear extracts of prostate adenomas.

  4. 4.

    Receptors for glucocorticoids are not detected in nuclei of prostate adenomas.

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Authors and Affiliations

  1. Laboratory of Endocrinology, Biology Department, M. V. Lomonosov Moscow State University, USSR

    Ts. I. Gerasimova, A. N. Smirnov & A. F. Bunyatyan

  2. Interclinical Hormone Laboratory, I. M. Sechenov First Moscow Medical Institute, USSR

    Ts. I. Gerasimova, A. N. Smirnov & A. F. Bunyatyan

Authors
  1. Ts. I. Gerasimova
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  2. A. N. Smirnov
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  3. A. F. Bunyatyan
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Additional information

Translated from Problemy Endokrinologii, Vol. 27, No. 6, pp. 28–33, November–December, 1981.

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Gerasimova, T.I., Smirnov, A.N. & Bunyatyan, A.F. Identification and characterization of the binding properties of steroid hormone receptors in the nuclear fraction of adenomas of the human prostate gland. Neurosci Behav Physiol 12, 484–488 (1982). https://doi.org/10.1007/BF01186863

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  • DOI: https://doi.org/10.1007/BF01186863

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