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Suppressing effect of hydrocortisone and corticotropin on the self-stimulation reaction

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Conclusions

  1. 1.

    Hydrocortisone has an inhibitory effect on the self-stimulation reaction frequency in rabbits, with the maximum effect being observed from 20 to 40 min after a single hormone injection.

  2. 2.

    Hormonal suppression of the positive reinforcement mechanism does not depend on whether the electrodes are placed in the anterior or posterior (where the self-stimulation reaction frequency is higher) areas of the lateral hypothalamus.

  3. 3.

    The effect of adrenocorticotropic hormone on the self-stimulation reaction is similar to that of hydrocortisone, but is less pronounced.

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Authors and Affiliations

  1. P. K. Anokhin Institute of Normal Physiology, Academy of Medical Sciences of the USSR, Moscow

    V. P. Belyi

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  1. V. P. Belyi
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Translated from Zhurnal Vysshei Nervnoi Deyatel'nosti, Vol. 29, No. 5, pp. 948–954, September–October, 1979.

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Belyi, V.P. Suppressing effect of hydrocortisone and corticotropin on the self-stimulation reaction. Neurosci Behav Physiol 11, 605–609 (1981). https://doi.org/10.1007/BF01186841

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  • DOI: https://doi.org/10.1007/BF01186841

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