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Influence of decrease in noradrenalin and serotonin levels in rat brain on defense and food-procuring conditioned reflexes

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Conclusions

  1. 1.

    Destruction of the locus coeruleus and n. raphe and the administration of disulfiram and PCPA led to a profound decrease in NA and 5-HT in anterior regions of the brain.

  2. 2.

    Destruction of the locus coeruleus impaired the development of the chain motor-food CR and slowed down the development of the food-procuring CR and defense CRA. The administration of disulfiram led to more profound disturbances in the development of these reflexes.

  3. 3.

    The administration of PCPA accelerated the development of CR, but led to complete absence of the capacity for the retention of chain motor-food CR and impaired the retention of the maze defense CR and defense CRA.

  4. 4.

    A decrease in 5-HT on the 8th day after destruction of the n. raphe led to a sharp disturbance in the retention of chain motor-food CR and to a decline in the retention of the food-procuring CR and defense CRA.

  5. 5.

    The decrease in 5-HT on the 15th day after destruction of the n. raphe, which was accompanied by a simultaneous decrease in the level of NA, led to the absence of the ability to develop chain motor-food and maze defense CR. The development of the food-procuring CR and the defense CI was not impaired, but their retention was sharply impaired.

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Authors and Affiliations

  1. Institute of Higher Neural Activity and Neurophysiology, Academy of Sciences of the USSR, Moscow

    R. M. Staikova, N. V. Orlova & V. M. Getsova

Authors
  1. R. M. Staikova
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  2. N. V. Orlova
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  3. V. M. Getsova
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Additional information

Translated from Zhurnal Vysshei Nervnoi Deyatal'nosti, Vol. 29, No. 5, pp. 962–969, September–October, 1979.

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Staikova, R.M., Orlova, N.V. & Getsova, V.M. Influence of decrease in noradrenalin and serotonin levels in rat brain on defense and food-procuring conditioned reflexes. Neurosci Behav Physiol 11, 581–587 (1981). https://doi.org/10.1007/BF01186837

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  • DOI: https://doi.org/10.1007/BF01186837

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