Abstract
The significance of the synthesis of the protein in the brain for the formation of intraspecies aggressive behavior of isolated males in early postnatal ontogenesis, under the influence of social contacts, was revealed in experiments on 200 mongrel rats. Chronic administration of cycloheximide (0.5 mg/kg; intraperitoneally), a protein synthesis blocker at the stage of translation, to infant rats from the 15th to the 30th postnatal days, prior to daily three-hour sessions of contacts between them, disrupted the formation of intraspecies aggressive behavior. This was manifested at adult age by their hyperaggressivity and by changes in the proportions of various reactions in the integral act of aggressive behavior.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature cited
P.K. Anokhin,Essays on the Physiology of Functional Systems [in Russian], Meditsina, Moscow (1975).
N. D. Dzhaparidze, R. S. Rizhinashvili, I. K. Svanidze, et al., “Change in the amount of cytoplasmic RNA in the neurons of the diencephalon of chicks during imprinting,”Soobshch. AN GSSR,121, No. 2, 409–415 (1986).
A. L. Rylov, “The reciprocal of different forms of aggressive behavior in rats,”Zhurn. Vyssh. Nervn. Deyat.,33, No. 6, 1151–1155 (1983).
A. L. Rylov, “A critical period in the formation of intraspecies aggressive behavior of rats and the maturation of neuromediator systems,” in:Summary of Reports of All-Union Conference “Mediators and Behavior“ [in Russian], Izd-vo SO AN SSSR, Novosibirsk (1988), p. 89.
R. O. Solomniya, N. M. Sobchinskaya, and D. G. Mikeladze, “Changes in the state of muscarinic brain cholinoreceptors during imprinting in chicks,”Neirokhimiya,6, No. 2, 180–183 (1987).
K. B. Sudakov, “Genic determination of physiological functions: experimental confirmation on the basis of the theory of functional systems,”Fiziol. Zh. SSSR,74, No. 1, 8–13 (1988).
K. B. Sudakov,General Theory of Functional Systems [in Russian], Meditsina, Moscow (1984).
D. Turmen,The Biochemistry of Cell Differentiation [Russsian translation], Mir, Moscow (1980).
H. P. Davis, M. R. Rosenzweig, E. L. Bennet, and A. E. Orme, “Recovery as a function of the degree of amnesia due to protein synthesis inhibition,”Pharmac. and Biochem. Behav.,8, No. 9, 701–711 (1978).
W. E. Hahn, N. Chaudari, and L. Beck, “Cold Spring Harbor Symposium on quantitative biology,”Molec. Neurobiol,48, 465–470 (1983).
J. S. Takahashi, “Anisomycin, and inhibitor of protein synthesis, perturbs the phase of a mammalian circadian pacemaker,”Brain Res.,405, No. 1, 199–203 (1987).
D. H. Thor and W. R. Holloway, “Social play in juvenile rats: a damage [sic] of methodological and experimental research,”Neurosci. and Biobehav. Res.,8, No. 4, 455–463 (1984).
R. N. Walsh, “Effects of environmental complexity and deprivation on brain chemistry and physiology. A review,”Intern. J. Neurosci.,11, No. 1, 77–83 (1980).
M. E. Zarvik and A. Geller, “The role of consolidation in memory,” in:Biochemistry of Brain and Behavior, R. E. Bowman (ed.), Plenum Press, New York (1970), pp. 245–277.
Author information
Authors and Affiliations
Additional information
Translated from Zhurnal Vysshei Nervnoi Deyatel'nosti imeni I. P. Pavlova, Vol. 40, No. 6, pp. 1149–1157, November–December, 1990.
Rights and permissions
About this article
Cite this article
Rylov, A.L., Anokhin, K.V. Synthesis of proteins in the critical periods of early postnatal ontogenesis: Its role in the formation of intraspecies aggressive behavior of rats. Neurosci Behav Physiol 22, 6–13 (1992). https://doi.org/10.1007/BF01186661
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF01186661