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State of the effect of long-term administration of thyrotrophin releasing hormone to rats on the posterior lobe of the pituitary

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Conclusions

  1. 1.

    Repeated injections of TRH (in a dose of 0.5 μg/100 g body weight) twice a day for 8 days leads to accumulation of NSS in the PLP of rats, which is indirect evidence of a reduction in the intensity of release of PLP hormones into the general bloodstream.

  2. 2.

    During long-term administration of TRH, no correlation is found between the NSS concentration in PLP and the plasma TSH and thyroid hormone levels.

  3. 3.

    If experimental animals are given diiodotyrosine in addition to TRH, the latter does not cause the plasma TSH level to rise.

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Authors and Affiliations

  1. Laboratory of Neuroendocrinology, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Academy of Sciences of the USSR, Leningrad

    I. A. Krasnovskaya & T. V. Tavrovskaya

Authors
  1. I. A. Krasnovskaya
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  2. T. V. Tavrovskaya
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Translated from Problemy Éndokrinologii, Vol. 30, No. 3, pp. 72–75, May–June, 1984.

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Krasnovskaya, I.A., Tavrovskaya, T.V. State of the effect of long-term administration of thyrotrophin releasing hormone to rats on the posterior lobe of the pituitary. Neurosci Behav Physiol 16, 169–172 (1986). https://doi.org/10.1007/BF01186519

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  • DOI: https://doi.org/10.1007/BF01186519

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