Conclusions
-
1.
Pirenperone, an antagonist of the serotonin2-receptors, in contrast to haloperidol, is a selective antagonist of apomorphine aggressiveness. Prolonged joint administration of definite doses of naloxone with apomorphine induces various subtypes of serotonin2-receptors, which is expressed in an inhibition of head shakings and the appearance of spontaneous aggressiveness after the administration of quipazine, a stimulator of serotonin2-receptors.
-
2.
Cholecystokinin tetrapeptide significantly enhances the electrical pain aggressiveness and, in the same doses, decreases the number of head shakings induced by quipazine. Pirenperone is a selective blocker of the action of cholecystokinin tetrapeptide.
-
3.
Cholecystokinin tetrapeptide may be an endogenous modulator of the sensitivity of the serotonin receptors. It is suggested that its functional role consists of activation of the serotonin2-receptors that turn on the defensive aggressive reactions.
Similar content being viewed by others
Literature cited
L. Kh. Allikmets, “Effects of adrenergic and serotoninergic substances on the behavior of amygdalectomized rats and on the aggressiveness induced by intraamygdalar injection of acetylcholine,” Zh. Vyssh. Nervn. Deyat.,25, No. 1, 164 (1975).
É. É. Vasar, M. Ya. Otter, and L. K. Ryago, “Intracerebroventricular injection of cholecystokinin inhibits the activity of the dopaminergic and serotoninergic systems of the brain,” Fiziol. Zh. SSSR,68, No. 9, 1218 (1982).
L. H. Allikmets, M. Stanley, and S. Gershon, “The effect of lithium on chronic haloperidol-enhanced apomorphine aggression in rats,” Life Sci.,25, 165 (1979).
H. R. Bürki, “Correlation between [3H]haloperidol binding in the striatum and brain amine metabolism in the rat after treatment with neuroleptics,” Life Sci.,23, 437 (1978).
F. C. Colpaert, C. J. E. Niemegeers, and P. A. J. Janssen, “A drug discrimination analysis of lysergic acid diethylamide:in vivo agonist and antagonist effects of purported 5-hydroxytryptamine antagonists and of pirenperone, an LSD antagonist,” J. Pharmacol. Exp. Therap.,221, 206 (1982).
C. M. Contreras, C. Guzman-Florez, M. E. Dorantes, F. R. Ervin, and R. Palmour, “Naloxone and phencyclidine: interacting effects of the limbic system and behavior,” Physiol. Behav.,27, 1019 (1981).
B. Costall and R. J. Naylor, “Stereotyped and circling behavior induced by dopaminergic agonists after lesions of the midbrain raphe nuclei,” Eur. J. Pharmacol.,29, 206 (1974).
N. R. Goltermann, K. Stengaard-Pedersen, J. F. Rehfeld, and N. J. Christensen, “Newly synthesized cholecystokinin in subcellular fractions of the rat brain,” J. Neurochem.,36, 959 (1981).
J. E. Leysen, W. Gommeren, and P. M. Laduron, “Spiperone: a ligand of choice for neuroleptic receptors. I. Kinetics and characteristics of in vitro binding,” Biochem. Pharmacol.,27, 307 (1978).
O. H. Lowry, N. J. Rosebrough, A. L. Farr, and R. J. Randall, “Protein measurement with the Folin reagent,” J. Biol. Chem.,193, 265 (1951).
S. J. Peroutka and S. H. Snyder, “Multiple serotonin receptors: differential binding of3H-5-hydroxytryptamine,3H-lysergic acid diethylamide, and3H-spiroperidol,” Mol. Pharmacol.,16, 687 (1979).
P. Seeman, “Brain dopamine receptors,” Pharmacol. Rev.,32, 229 (1981).
R. J. Sbordone, D. A. Gorelick, and M. L. Elliott, “An ethological analysis of drug-induced pathological aggression,” in: Multidisciplinary Approaches to Aggression Research, P. F. Brain and D. Benton (eds.). Elsevier North Holland Biomedical Press (1981), p. 369.
M. E. Trulson and T. Crisp, “Behavioral and neurochemical effects of apomorphine in the cat,” Eur. J. Pharmacol.,80, 295 (1982).
Author information
Authors and Affiliations
Additional information
Translated from Zhurnal Vysshei Nervnoi Deyatel'nosti imeni I. P. Pavlova, Vol. 34, No. 2, pp. 283–289, March–April, 1984.
Rights and permissions
About this article
Cite this article
Vasar, É.É., Maimets, M.O. & Allikmets, L.K. Role of the serotonin2-receptors in regulation of aggressive behavior. Neurosci Behav Physiol 16, 118–124 (1986). https://doi.org/10.1007/BF01186509
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01186509