Conclusions
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1.
The administration of prednisolone to infant rats at the age of 17–19 days induces a significant decrease in the amplitude of the diurnal rhythms of the content of corticosteroids in the blood and in the volumes of the nuclei of the cells of the external portion of the zona fasciculata, and a disappearance of the diurnal periodicity of the relative area of the zona fasciculoreticularis of the adrenocortex in the adult animals.
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2.
The suppression of the diurnal periodicity of adrenocortical activity in the adult animals under the influence of hormonal dysbalance in early postnatal ontogenesis is associated with a disturbance in the mechanisms of the cyclical liberation of neurohormones from the neurohypophysis and hypothalamus: the disappearance of the diurnal periodicity of the content of NSM in the external zone of the median eminence and in the posterior lobe of the hypophysis is observed, as is a decrease in the amplitude of the diurnal rhythm of the volume of the nucleoli of the NSC of the PVN of the hypothalamus, with a shift of the maximum to the morning hours of the day as compared with the nocturnal peak in the control animals.
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Translated from Problemy Éndokrinologii, Vol. 36, No. 6, pp. 58–62, November–December, 1990.
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Zlobina, N.A., Lur'e, S.B. & Danilova, O.A. Influence of the administration of prednisolone in early postnatal ontogenesis on the diurnal activity of the hypothalamic-hypophyseal-adrenocortical system of adult rats. Neurosci Behav Physiol 21, 532–535 (1991). https://doi.org/10.1007/BF01185945
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DOI: https://doi.org/10.1007/BF01185945