Conclusions
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1.
An excess of 5-HT in the brain disturbs fixation of defensive, drinking, and foodgetting conditioned reflexes to a greater degree than a fall in its level.
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2.
The negative effect of an excess of 5-HT on fixation of conditioned reflexes is unaccompanied by any effect on their formation.
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3.
The degree of involvement of the serotoninergic system of the brain in the consolidation of conditioned reflexes depends on the character and particular features of the conditioned reflexes formed.
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Literature cited
I. M. Aivazashvili, G. S. Iordanishvili, and V. N. Chikvaidze, Dokl. Akad. Nauk SSSR,212, No. 6, 1472 (1973).
M. L. Voronina and N. A. Tushmalova, Zh. Vyssh. Nerv. Deyat.,13, No. 3, 1071 (1963).
E. A. Gromova, T. N. Semenova, and N. L. Vekshina, Dokl. Akad. Nauk SSSR,227, No. 3, 366 (1976).
V. A. Krauz, in: Memory in Mechanisms of Normal and Pathological Reactions [in Russian], Meditsina, Moscow (1976), p. 122.
R. I. Kruglikov, V. M. Getsova, and M. L. Maizelis, Zh. Vyssh. Nerv. Deyat.,25, No. 1, 51 (1975).
R. I. Kruglikov, V. M. Getsova, and M. Unial, Zh. Vyssh. Nerv. Deyat.,26, No. 6, 1208 (1976).
R. I. Kruglikov and N. V. Orlova, Zh. Vyssh. Nerv. Deyat.,26, No. 1, 120 (1976).
R. Stajkova, Zh. Vyssh. Nerv. Deyat.,27, No. 6, 1257 (1977).
V. P. Podachin, in: “Problems in the physiology of the central nervous system,” Tr. Fiziol. Lab. Akad. Nauk SSSR, No. 1, 37 (1959).
M. H. Aprison, J. N. Hington, and W. J. McBridge, Fed. Proc,34, 1813 (1975).
L. Cook and E. Weidley, Ann. N.Y. Acad. Sci.,66, 740 (1957).
J. A. Deutsch, Science,174, No. 5, 150 (1971).
R. K. Dismukes and A. V. Rake, Psychopharmacologia,29, 91 (1973).
W. B. Essman, Biology of Memory, Plenum Press, New York (1971), p. 213.
W. B. Essman, Advances Biochem. Psychopharmacol.,11, 265 (1974).
D. A. Gorelik, F. R. Rozewicz, and W. H. Bridger, in: Catecholamines and Behavior, Vol. 2, Neuropsychopharmacology, A. J. Friedhoff, ed., Plenum Press, New York (1975).
M. E. Jarvik and A. Kopp, Psychol. Rep.,21, 221 (1967).
F. P. Miller, R. M. Cox, W. R. Snodgrass, and R. P. Maickel, Biochem. Pharmacol.,19, 435 (1970).
N. J. Polermo, F. V. Carvalho, and J. Melito, Arch. Internat. Pharmacodyn.,222, 300 (1976).
H. Rigter and H. Van Riezen, Physiol. Behav.,14, 563 (1975).
B. Srebro, F. Jellestad, and S. A. Zorens, Exp. Brain Res.,23, 381 (1975).
D. A. Stevens, Life Sci.,9, 1127 (1970).
C. Tanaka, H. Y. Yo, and S. Takaori, Brain Res.,45, 153 (1972).
S. Udenfriend, H. Weissbach, and C. J. Clark. J. Biol. Chem.,215, 337 (1955).
A. S. Welch and B. L. Welch, J. Pharm. Pharmacol.,19, 632 (1967).
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Translated from Zhurnal Vysshei Nervnoi Deyatel'nosti, Vol. 29, No. 4, pp. 737–744, July–August, 1979.
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Getsova, V.M. Effect of serotonin on formation and fixation of various conditioned reflexes. Neurosci Behav Physiol 11, 280–285 (1981). https://doi.org/10.1007/BF01184423
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DOI: https://doi.org/10.1007/BF01184423