Abstract
The content of chlorinated hydrocarbons (CHC) was determined by means of capillary column gas chromatography in samples of fat tissue from 183 healthy children, 46 children with malignant tumors and 33 children with benign tumors or congenital malformations. The highest concentrations were found for total polychlorobiphenyls (PCB) (−x=1.614 ppm), followed by the DDT group (−x=0.556 ppm, HCB (−x=0.097 ppm), the HCH isomers (−x=0.083 ppm), dieldrin (−x=0.020 ppm) and total heptachlor (−x=0.010 ppm). Neonates displayed high concentrations in the adipose tissue before, the first uptake of food. In the first six months of life, the concentrations of total PCB, the individual PCB components as well as DDT and HCB decreased significantly. In the second year of life, they rose again to the initial values and then remained relatively constant during the rest of childhood. The regional differences with regard to total CHC residues were slight, so that the CHC exposure cannot be reduced by a change of domicile within West Germany (FRG). Children with congenital malformations or benign or malignant tumors do not display raised concentrations of CHC.
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Abbot DC, Collins GB, Goulding R, Hoodless RA (1981) Organochlorine pesticide residues in human fat in the United Kingdom 1976–7. Br Med J 283:1425–1428
Allen JR, Barsotti DA, Carstens LA (1980) Residual effects of polychlorinated biphenyls on adult nonhuman primates and their offsprings. J Toxicol Environ Hlth 6:55–66
Allen JR, Barsotti DA, Lambrecht L, van Miller J (1979a) Reproductive effects of halogenated aromatic hydrocarbons on nonhuman primates. Ann NY Ac Sci 320:419–425
Allen JR, Hargraves WA, Hsia MTS, Lin FSD (1979b) Comparative toxicology of chlorinated compounds on mammalian species. Pharmac Ther 7:523–547
Ballschamiter K, Zell M (1980) Analysis of polychlorinated biphenyls (PCB) by glass capillary gas chromatography. Fresenius Zs anal Chem 302:20–31
Beck H, Mathar W (1983) Zur Bestimmung von PCB in Lebensmitteln. Tätigkeitsbericht 1983 des Bundesgesundheitsamtes, München
Brassow HL, Baumann K, Lehnert G (1981) Occupational exposure to hexachlorcyclohexane. II Health conditions of chronically exposed workers. Int Arch Occup Environ Hlth 48:81–87
CLUA Baden-Württemberg (1987) Humanmilchuntersuchungen 1980–1986
Costa LG (1987) Toxicology of pesticides: A brief history. In: Costa LG, Galli CL, Murphy SD (eds) Toxicology of pesticides: Experimental, clinical and regulatory perspectives. Springer, Berlin, pp 1–10
Courtney KD (1979) Hexachlorbenzene (HCB): A review. Environ Res 20:225–266
DFG/Deutsche Forschungsgemeinschaft (1984) Rückstände und Verunreinigungen in Frauenmilch. Mitteilung XII, Verlag Chemie, Weinheim
Dolphin RJ, Willmot FW, Mills FW, Hoogeveen LPJ (1976) Column switching technique in the liquid chromatographic analysis of organochlorine pesticides in milk. J Chromatogr 122:259–268
Engelhardt H (1977) Hochdruckflüssigkeitschromatographie. Springer, Berlin, 2. Auflage
Faith RE, Luster ME Vos, (1980) Effects on immunocompetence by chemicals of environmental concern. Rev Biochem Toxicol 2:173–211
Heeschen W, Hahne KH, Blüthgen A (1984) Untersuchungen zur Situation und Entwicklung der Rückstände chlorierter Kohlenwasserstoffe in Frauenmilch unter Berücksichtgung anamnestischer Daten wie Ernährung, Umwelt, Sozialgefüge u.a. 2. Zwischenbericht, Kiel
Hermanowicz A, Nawarska Z, Borys D, Maslankiewicz A (1982) The neutrophil function and infectious diseases in workers occupationally exposed to organochloride insecticides. Int Arch Occup Environ Health 50:329–340
Holt RL, Cruse S, Greer ES (1986) Pesticide and polychlorinated biphenyl residues in human adipose tissue from Northeast Louisiana. Bull Environ Contam Toxicol 36:651–655
IARC/International Agency for Research of Cancer (1979a) Heptachlor and Heptachlor Epoxide. IARC Monogr Eval Carcinog Risk Chem Hum 20:129–154
— (1979b) Hexachlorobenzene. IARC Monogr Eval Carcinog Risk Chem Hum 20:155–178
— (1979c) Hexachlorocyclohexane (Technical HCH and Lindane) IARC Monogr Eval Carcinog Risk Chem Hum 20:195–239
Infante PF, Epstein SS, Newton WA Jr (1978) Blood dyscrasias and childhood tumors and exposure to chlordane and heptachlor. Scand J Work Environ Hlth 4:137–150
Karakaya AE, Özalp S (1987) Organochlorine pesticides in human adipose tissue collected in Ankara (Turkey) 1984–1985 Bull Environ Contam Toxicol 38:941–945
Kruskall WH, Wallis WA (1952) Use of ranks in one criterion variance analysis. J Am Stat Assoc 47:614–617
Kutz FW, Yobs AR, Strassman BS (1977a) Racial stratification of organochlorine insecticide residues in human adipose tissue. J Occup Med 19:619–622
McConnell EE (1980) Acute and chronic toxicity, carcinogenesis, reproduction, teratogenesis and mutagenesis in animals. In: Kimbrough RD (ed): Halogenated biphenyls, terphenyls, naphthalenes, dibenzodioxins and related products. Elsevier/North Holland, Biochemical Press, New York, pp 109–150
Mes J, Davies DJ, Turton D (1982) Polychlorinated biphenyl and other chlorinated hydrocarbon residues in adipose tissue of Canadians. Bull Environ Contam Toxicol 28:97–104
— (1982) Environmental contaminants in human fat: a comparison between accidental and nonaccidental causes of death. Ecotoxicol Environ Safety 10:70–74
Mori Y, Kikuta M, Okinaga E, Okura T (1983) Levels of PCBs and organochlorine pesticides in human adipose tissue collected in Ehime prefecture. Bull Environ Contam Toxicol 30:74–79
Mukherjee D, Ghosh BN, Chakraborty J, Roy BR (1980) Pesticide residues in human tissues in Calcutta. Indian J Med Res 72:583–587
Niessen KH, Ramolla J, Binder M, Brügmann G, Hofmann U (1984) Chlorinated hydrocarbons in adipose tissue of infants and toddlers: Inventory and studies on their association with intake of mothers' milk. Eur J Pediatr 142:238–243
Ramachandran M, Banerjee BD, Gulati M, Grover A (1984) DDT and HCH residues in the body fat and blood samples from some Delhi hospitals. Indian J Med Res 80:590–593
Sawyer LD (1973) Collaborative study of the recovery and gas chromatographic quantitation of polychlorinated biphenyls in chicken fat and polychlorinated biphenyl-DDT combinations in fish. J Assoc Offic Anal Chem 56:1015–1023
Sevcik J, Lenicek J, Citkova M, Sekyra M, Rychlikova E (1986) The polychlorinated biphenyls load for the children's organism. Cesk Hyg 31:378–382
To-Figueras J, Rodamilans M, Gomez J, Corbella J (1986) Hexachlorobenzene residues in the general population of Barcelona (Spain). IARC Sci Pub 77:147–148
Widdowson EM (1985) Wachstum und Zusammenstzung des menschlichen Körpers in der Kindheit. In: Die Ernährung des Säuglings und Kleinkindes, Nestle Nutrition, Vevey, Raven Press, New York, pp 1–14
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The study was carried out with financial support from the Federal Ministry of Research and Technology (BMFT) of the Federal Republic of Germany.
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Teufel, M., Niessen, K.H., Sartoris, J. et al. Chlorinated hydrocarbons in fat tissue: Analyses of residues in healthy children, tumor patients, and malformed children. Arch. Environ. Contam. Toxicol. 19, 646–652 (1990). https://doi.org/10.1007/BF01183979
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DOI: https://doi.org/10.1007/BF01183979