Conclusions
-
1.
The administration of mice, thymectomized at the third day of age, of T3 fraction 5 in the first month of life, leads to the formation of reduced function of the adrenals in male and female adult animals.
-
2.
The administration of T3 in vitro suppresses the hormonal function of the adrenal cortex in male and female mice.
-
3.
The administration of T3 to adult male mice in vivo reduces the production of adrenal cortical glucocorticoids.
-
4.
The significant activity which T3 manifests in relation to the adrenals, makes it possible to assume that the diverse influence of the thymus on the endocrine system may be mediated by this preparation.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature cited
L. N. Maslova and N. V. Ryazantseva, Izv. SO AN SSSR: Seriya Biol. Nauk,1, 104–109 (1984).
D. Müller and P. Dukor, The Biology of the Thymus [translated from German], Moscow (1967).
R. I. Salganik, V. G. Selyatinskaya and Yu. P. Shorin, Ontogenez,6, 625–627 (1979).
A. A. Tinnikov and N. M. Bazhan, Lab. Delo,2, 709–713 (1984).
V. M. Chesnokova, V. M. Yunker, L. N. Ivanovna and E. V. Gruntenko, Byull. Éksp. Biol.,3, 102–104 (1982).
V. M. Chesnokova, L. N. Ivanovna and E. V. Gruntenko, Byull. Éksp. Biol.,8, 89–91 (1983).
L. Allen et al., J. Reprod. Immunol.,6, 143–149 (1984).
J. F. Bach et al., Transpl. Proc.,7, 25–30 (1975).
P. Deschaux, J. Flores and P. Fontanges, C. R. Soc. Biol.,167, 987–993 (1973).
A. Goldstein et al., Recent Prog. Hormone Research,37, 369–415 (1981).
D. Healy et al., Science,222, 1353–1355 (1983).
T. Ma, A. Ho and A. Hoffbrand, Clin. Exp. Immunol.,55, 273–280 (1984).
S. Martin and G. Moders, Life Sci.,29, 143–149 (1981).
E. Michael, O. Toguchi and J. Nishisuka, Biol. Reprod.,22, 343–350 (1980).
J. Nishisuka and T. Sakakura, Endocrinology,89, 886–892 (1971).
W. Pierpaoli H. Besedovsky, Clin. Exp. Immunol.,20, 323–328 (1975).
H. Van-Dijk and H. Jacobs-Geels, Immunology,35, 637–642 (1978).
Author information
Authors and Affiliations
Additional information
Translated from Problemy Endokrinologii. Vol. 33, No. 1, pp. 56–60, January–February, 1987.
Rights and permissions
About this article
Cite this article
Chesnokova, V.M., Ignat'eva, E.V., Ivanova, L.N. et al. Influence of thymosin on the formation of the functional activity of the adrenals in mice. Neurosci Behav Physiol 17, 353–357 (1987). https://doi.org/10.1007/BF01183067
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01183067