Skip to main content
SpringerLink
Log in

Modulation by Ca ions of short-term plasticity of the cholinoreceptive membrane in molluscan neurons

  • Published:
Neuroscience and Behavioral Physiology Aims and scope Submit manuscript

Conclusions

  1. 1.

    Repeated ionotophoretic applications of acetylcholine to the external surface of the membranes of identified neurons of a mollusc cause a gradual, reversible lowering of the sensitivity of the cholinoreceptors.

  2. 2.

    The effect on the calcium conductance of the neuronal membranes modifies the dynamics involved in the lowering of cholinoreceptor sensitivity during repeated applications of acetylcholine.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature cited

  1. B. N. Vepritsev, “Association of the electrical activity of the nerve cell with the synthesis of RNA within it and the role of the cell membrane in regulating the biosynthesis of RNA in the cell,” Dissertation, Institute of Biophysics of the USSR, Pushchino-on-Oka (1971).

    Google Scholar 

  2. P. A. Doroshenko and A. Ya. Tsyndarenko, “The action of calcium on inward calcium current,” Neirofiziologiya,10, No. 2, 203 (1978).

    Google Scholar 

  3. T. L. D'yakonova and T. M. Turpaev, “The plasticity of the electroexcitable membrane of the neuron,” Dokl. Akad. Nauk SSSR,271, No. 5, 1261 (1983).

    Google Scholar 

  4. P. G. Kostyuk and O. A. Krystal', Mechanisms of Electrical Excitation of the Nerve Cell [in Russian], Nauka, Moscow (1981).

    Google Scholar 

  5. A. Kotyk and K. Ynachek, Membrane Transport. An Interdisciplinary Approach [Russian translation], Mir, Moscow (1980).

    Google Scholar 

  6. S. A. Kudunov, Ca2 Transport System within the Cell [in Russian], Naukova Dumka, Kiev (1983).

    Google Scholar 

  7. Yu. G. Plyashkevich, “Structural features of the recognition sites of cholinergic ligands and AChR of the squid,” Vses. Kardiol. Nauchn. Tsentr AMN SSSR (1984).

  8. M. A. Poskonova, B. Yu. Dafengauz, and N. E. Babskaya, “The effect of verapamil D-600 and papaverine on the sensitivity of denervated muscle to acetylcholine,” Dokl. Akad. Nauk SSSR,247, No. 4, 1003 (1979).

    PubMed  Google Scholar 

  9. D. A. Sakharov, The Genealogy of Neurons [in Russian], Nauka, Moscow (1974).

    Google Scholar 

  10. N. V. Kramtsov, “An investigation of the muscarinic receptor of acetylcholine by directed chemical modification,” Dissertation, Institute of Bioorg. Chem., Akad. Nauk SSSR (1983).

    Google Scholar 

  11. D. J. Adams, T. M. Dwyer, and B. Hille, “The permeability of endplate channels to monovalent and divalent metal cations,” J. Gen. Physiol.,75, No. 5, 493 (1980).

    PubMed  Google Scholar 

  12. D. L. Alkon, “Learning in a marine snail,” Sci. Am.,249, No. 1, 64 (1983).

    Google Scholar 

  13. P. Ascher, A. Marty, and T. O. Nield, “Lifetime and elementary conductance of the channels mediating the excitatory effects of acetylcholine inAplysia neurones,” J. Physiol.,278, 177 (1978).

    PubMed  Google Scholar 

  14. P. D. Bregestovski and V. I. Iljin, “Effect of ‘calcium antagonist’ D-600 on the postsynaptic membrane,” J. Physiol. (France),76, No. 5, 515 (1980).

    Google Scholar 

  15. P. D. Bregestovski, R. Miledi, and I. Parker, “Calcium conductance of acetylcholine-induced endplate channels,” Nature,279, No. 5714, 638 (1979).

    PubMed  Google Scholar 

  16. T. V. Dunwiddie and G. Lynch, “The relationship between extracellular calcium concentrations and the induction of hippocampal long-term potentiation,” Brain Res.,169, No. 1, 103 (1979).

    PubMed  Google Scholar 

  17. J. C. Eccles, “Calcium in long-term potentiation as a model for memory,” Neuroscience,10, No. 4, 1071 (1983).

    PubMed  Google Scholar 

  18. S. D. Frulkar and A. Fine, “Calcium in the nervous system,” Rev. Neurosci.,4, 179 (1979).

    Google Scholar 

  19. K. Krnjevic and A. Lisiewicz, “Injections of calcium ions into spinal motoneurons,” J. Physiol. (Engl.),225, No. 2, 363 (1972).

    Google Scholar 

  20. K. Kusano, R. Miledi, and J. Stinnakre, “Postsynaptic entry of calcium induced by transmitter action,” Proc. Roy. Soc., Ser. B,189, No. 1094, 49 (1975).

    Google Scholar 

  21. G. Lynch, J. Larson, S. Kelso, G. Barrionuevo, and F. Schottler, “Intracellular injections of EGTA block induction of hippocampal long-term potentiation,” Nature,305, No. 5936, 719 (1983).

    PubMed  Google Scholar 

  22. N. B. Standen, “Ca-channel inactivation by intracellular Ca injection intoHelix neurons,” Nature,293, No. 5828, 158 (1981).

    PubMed  Google Scholar 

  23. T. Tokimasa and R. A. North, “Calcium entry through acetylcholine channels can activate potassium conductance in bullfrog sympathetic neurons,” Brain Res.,295, No. 2, 364 (1984).

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Higher Nervous Activity, M. V. Lomonosov State University, Moscow

    A. S. Pivovarov & G. N. Saganelidze

Authors
  1. A. S. Pivovarov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. N. Saganelidze
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Translated from Zhurnal Vysshei Nervnoi Deyatel'nosti imeni I. P. Pavlova, Vol. 36, No. 5, pp. 947–955, September–October, 1986

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pivovarov, A.S., Saganelidze, G.N. Modulation by Ca ions of short-term plasticity of the cholinoreceptive membrane in molluscan neurons. Neurosci Behav Physiol 17, 288–296 (1987). https://doi.org/10.1007/BF01183057

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01183057

Keywords

Search

Navigation