Abstract
We have recorded extracellularly the impulse activity of the rat medulla oblongata during stimulation of taste receptors of the tongue and visceral chemoreceptors with solutions of hydrochloric acid and sodium chloride. We have detected in the caudal region of the nucleus of the solitary tract, neurons that react to the chemical stimulation of either one or both the receptive zones mentioned. The response reactions of the isolated groups of units (taste, viscerochemical, and convergent neurons) are tonic and are characterized by a high level of impulse activity. We have established that the neurons of each of the groups isolated are capable of discriminating between salt and acid solutions. Using the example of sodium chloride solutions we have shown that an increase in the number of viscerochemical neurons which inhibit their own background activity on increase in the concentration of any substance in the intestine is an important index of the satiation of an animal and can serve as a starting link in the mechanism of food rejection.
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Literature cited
N. E. Vasilevskaya, “Dependence of the conditioned food reflexes on the state of the internal analyzer,” Fiziol. Zh. SSSR,41, No. 2, 204–209 (1955).
N. E. Vasilevskaya, The Functions and Structure of the Viscerochemical Analyzer [in Russian], Leningrad State University, Leningrad (1971), p. 190.
I. P. Nikitina, “Dependence of interoceptive and exteroceptive reflexes on limited entry of salt into the body,” Dokl. Akad. Nauk SSSR,114, No. 4, 901–903 (1957).
I. P. Nikitina, “Feeding behavior of dogs under conditions of normal and experimentally changed water-salt metabolism,” Vestn. LGU (Leningrad State University), Ser. Biol.,2, 94–105 (1966).
K. Pfaffman, R. Erickson, J. Frommer, and B. Halpern, “Discharges of neurons of the medulla oblongata and thalamus on action of taste stimulants,” in: Theory of Association in Sensory Systems [Russian translation], Mir, Moscow (1964), pp. 137–152.
A. M. Ugolev and V. G. Kassil', “Feeding behavior and regulation of homeostasis,” in: Complex Forms of Behavior [in Russian], Moscow-Leningrad (1965), pp. 41–57.
V. Yu. Urbach, Mathematical Statistics for Use in Biology and Medicine, Academy of Sciences of the USSR, Moscow (1963), p. 322.
V. N. Chernigovskii, Significance of Interoceptive Signalization in the Feeding Behavior of Animals [in Russian], Nauka, Moscow-Leningrad (1962), p. 54.
G. K. Shlygin, “Secretory activity of the small intestine,” in: Manual of Physiology; Physiology of Digestion [in Russian], Nauka, Leningrad (1974), p. 758.
A. J. Blomquist and A. Antem, “Gustatory deficit produced by medullary lesions in the white rat,” J. Comp. Physiol. Psychol.,63, No. 3, 439–443 (1967).
G. S. Doetsch and R. P. Erickson, “Synaptic processing of taste. Quality information in N. T. S. of rat,” J. Neurophysiology,33, No. 4, 490–507 (1976).
R. P. Erickson, “Sensory neural pattern and gustation,” in: Olfaction and Taste, Pergamon Press, Oxford (1963), Vol. 1, pp. 205–213.
R. P. Erickson, “Stimulus coding in topographic and nontopographic afferent modalities,” Psychol. Rev.,75, 447–465 (1968).
R. P. Erickson, G. S. Doetsch. and D. A. Marshall, “Gustatory neural response function,” J. Gen. Physiol.,49, 247–263 (1965).
H. Grill and R. Norgren, “Chronically decerebrated rats demonstrate satiation but not bait shyness,” Science,201, 4352 (1978).
R. Norgren and C. M. Leonard, “Ascending central gustatory pathways,” J. Comp. Neurol.,150, No. 2, 217–237 (1973).
C. P. Richter, “Salt taste thresholds of normal and adrenalectomized rats,” Endocrinology,24, 367–371 (1939).
G. F. Rossi and A. Broudal, “Spinal afferent to the trigeminal sensory nuclei and the nuclei of the solitary tract,” Cofin. Neurol.,16, 321–322 (1956).
A. Torvik, “Afferent connections to the sensory trigeminal nuclei, the nucleus of the solitary tract, and adjacent structure,” J. Comp. Neurol.,106, No. 1, 51–132 (1956).
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Translated from Fiziologicheskii Zhurnal SSSR imeni I. M. Sechenova, Vol. 68, No. 10, pp. 1337–1343, October, 1982.
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Vasilevskaya, N.E., Zharova, L.T. & Gulyakov, M.B. Impulse activity of medulla oblongata in rats in response to stimulation of taste receptors and visceral chemoreceptors. Neurosci Behav Physiol 15, 247–253 (1985). https://doi.org/10.1007/BF01182995
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DOI: https://doi.org/10.1007/BF01182995