Abstract
The effect of experimentally induced generalized seizures on the relations between the various phases of sleep in the wakefulness-sleep cycle was studied in cats with chronically implanted electrodes. After generalized convulsions induced by electrical stimulation of the dorsal hippocampus, unlike those of amygdalar origin, clearly defined changes were observed in the structure of the wakefulness-sleep cycle. In the postseizure period, with increasing wakefulness sharp depression of paradoxical sleep takes place. However, in slow wave sleep only slight changes were observed. Instead of a rebound phenomenon, paradoxical sleep was sharply induced in cats after preliminary deprivation of paradoxical sleep as a result of generalized seizures induced by electrical stimulation of the neocortex. Nonspecific hyperactivation of the brain, in the form of epileptiform discharges, thus has a particularly marked effect on the structure of paradoxical sleep.
Similar content being viewed by others
Literature cited
M. G. Koridze, M. M. Mgaloblishvili, and M. G. Kavkasidze, in: The Neurophysiology of Emotions and the Wakefulness-Sleep Cycle [in Russian], Vol. 2, Metsniereba, Tbilisi (1976), p. 63.
Z. I. Nanobashvili and T. J. Ioseliani, Soobshch. Akad. Nauk Gruz. SSR,69, 429 (1973).
T. N. Oniani and T. K. Kapanadze, Soobshch. Akad. Nauk Gruz. SSR,51, 477 (1968).
T. N. Oniani, M. G. Koridze, M. G. Kavkasidze, and L. B. Gvetadze, in: The Neurophysiology of Emotions and the Wakefulness-Sleep Cycle [in Russian], Vol. 2, Metsniereba, Tbilisi (1976), p. 28.
L. Chocholova and T. Radil-Weiss, Activ. Nerv. Sup.,11, 242 (1969).
H. B. Cohen and W. C. Dement, Science,154, 396 (1966).
C. Ferre, Les Epilepsies et les Epileptiques, Alcan, Paris (1890).
C. J. Frederickson and J. A. Hobson, Psychophysiol. Psychiat. Clin.,6, 271 (1969).
P. Halasz, Acta Physiol. Acad. Sci. Hung.,42, 293 (1972).
R. Hernandez-Peon and R. Guerrero-Figueroa, Acta Neurol. Latinoam.,11, 224 (1965).
J. D. Hobson, Science,162, 1503 (1968).
J. Hunter and H. H. Jasper, Electroenceph. Clin. Neurophysiol.,1, 305 (1949).
M. Jouvet, Physiol. Rev.,47, 117 (1967).
M. Mancia and R. Lucioni, Epilepsia,7, 308 (1966).
R. Mutani, Epilepsia,8, 73 (1967).
Passouant, J. Latour, J. Minvielle, and R. Cadilhac, Rev. Neurol.,87, 218 (1952).
P. Passouant, A. Besset, A. Carrier, and M. Billiard, Sleep, Second European Congress on Sleep Research, Rome, 1974, Karger, Basel (1975), p. 185.
P. T. S. Putkonen and A. R. Putkonen, Brain Res.,26, 333 (1971).
E. Roldan, Activ. Nerv. Sup.,11, 247 (1969).
T. Radil-Weiss and E. Roldan, Biol. Inst. Estud. Med. Biol.,22, 1 (1964).
Author information
Authors and Affiliations
Additional information
Translated from Fiziologicheskii Zhurnal SSSR imeni I. M. Sechenova, Vol. 63, No. 5, pp. 617–625, May, 1977.
Rights and permissions
About this article
Cite this article
Koridze, M.G., Mgaloblishvili, M.M. & Kavkasidze, M.G. Effect of experimentally induced generalized seizures on the wakefulness-sleep cycle. Neurosci Behav Physiol 8, 311–316 (1977). https://doi.org/10.1007/BF01182907
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01182907