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Effect of clomiphene on the restoration of ovulation in androgen-sterile rats

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Conclusions

  1. 1.

    In androgen-sterile rats given 10–250 μ TP in the early postnatal perid, upon sexual maturation there was a decrease in hypothalamic LH-RF, in hypophyseal and blood LH, in ovarian weight and number of corpora lutea, and in blood testosterone and progesterone; there was an increase in the dopamine level of the anterior hypothalamus.

  2. 2.

    Clomiphene administration for 5 days to androgen-sterile rats, particularly to rats given earlier 10 μ TP, Ied to a normalization of these indices and to the onset of ovulation.

  3. 3.

    Short-term clomiphene administration to androgen-sterile rats (5 days), as well as prolonged administration (1 month), restored the capacity for pregnancy.

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Authors and Affiliations

  1. Laboratory of Physiology and Pathology of the Human Endocrine System, I. P. Pavlov Institute of Physiology, Academy of Sciences of the USSR, Moscow

    V. G. Baranov, M. E. Kogan, M. V. Propp, F. I. Proimina & O. N. Savchenko

  2. Endocrinology Division, Institute of Obstetrics and Gynecology, Academy of Medical Sciences of the USSR, Moscow

    V. G. Baranov, M. E. Kogan, M. V. Propp, F. I. Proimina & O. N. Savchenko

Authors
  1. V. G. Baranov
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  2. M. E. Kogan
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  3. M. V. Propp
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  4. F. I. Proimina
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  5. O. N. Savchenko
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Additional information

Translated from Problemy Éndokrinologii, Vol. 23, No. 1, pp. 60–64, January–February, 1977.

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Baranov, V.G., Kogan, M.E., Propp, M.V. et al. Effect of clomiphene on the restoration of ovulation in androgen-sterile rats. Neurosci Behav Physiol 8, 271–274 (1977). https://doi.org/10.1007/BF01182898

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  • DOI: https://doi.org/10.1007/BF01182898

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