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Effects of testosterone and its 5α-reduced metabolites on serum luteinizing hormone and hypothalamic luliberin levels in the castrated rat. Communication I.

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Conclusions

  1. 1.

    Fundamental differences were uncovered in the effects of T and its 5α-reduced metabolites on the HHS of male rats, both in terms of the effect and the time of onset of action.

  2. 2.

    3β-diol appears to be an active intermediate, along with 3α-diol and DHT, in the negative feedback loop between the gonads and the HHS.

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Authors and Affiliations

  1. Fourth Main Administration, Ministry of Health in the USSR, Moscow

    L. A. Loseva, V. G. Degtyar' & V. A. Isachenkov

Authors
  1. L. A. Loseva
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  2. V. G. Degtyar'
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  3. V. A. Isachenkov
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Additional information

Translated from Problemy Éndocrinologii, Vol. 26, No. 6, pp. 46–50, November–December, 1980.

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Loseva, L.A., Degtyar', V.G. & Isachenkov, V.A. Effects of testosterone and its 5α-reduced metabolites on serum luteinizing hormone and hypothalamic luliberin levels in the castrated rat. Communication I.. Neurosci Behav Physiol 11, 437–440 (1981). https://doi.org/10.1007/BF01182792

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  • DOI: https://doi.org/10.1007/BF01182792

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