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Effects of acetylcholine, norepinephrine, and serotonin on neurons of the septumin vitro

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Conclusions

  1. 1.

    Neurons of slices of the septum are equally highly reactive to ACh, NA, and 5-HT introduced into the reaction medium (86–88% of the neurons change their level or the nature of their spontaneous activity).

  2. 2.

    A predominance of activation effects are characteristic of NA and ACh (strong and developing rapidly in the first case, weaker and gradual in the second). 5-HT suppresses and increases the activity of the neurons to an equal degree.

  3. 3.

    Only ACh causes the appearance, intensification, or increase in the frequency of the rhythmic volley activity. In certain cells the volleys evoked by ACh are removed in a medium with a high Mg2+ content, while in others they are preserved.

  4. 4.

    Cells of the septum with regulatory activity of the pacemaker type, on the whole, are less reactive to the action of substances and Mg2+ than neurons with nonregulatory activity. In cases of reactivity of these cells to the indicated influences, an increase or decrease in the average frequency occurs without any disturbance of the regularity of the spike discharges. It is suggested that mediator substances act on part of the cells of the septum as modulators of the endogenous pacemaker mechanism.

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Literature cited

  1. S. D. Zhadina and O. S. Vinogradova, “Influence of acetylcholine and glutamate on septal neuronsin vitro,” Zh. Vyssh. Nervn. Deyat.,30, No. 2, 392 (1980).

    Google Scholar 

  2. J. F. De France, R. A. McGrea, and H. Yoshihara, “Effects of certain indoleamines in the hippocampal-septal circuit,” Expt. Neurol.,48, No. 2, 352 (1975).

    Google Scholar 

  3. J. F. De France, H. Yoshihara, R. A. McGrea, and S. T. Kitai, “Pharmacology of the inhibition in the lateral septal region,” Exp. Neurol.,48, No. 3, 502 (1975).

    Google Scholar 

  4. F. G. Graeff, S. Quntero, and J. A. Gray, “Median raphe stimulation, hippocampal theta rhythm, and threat-induced behavioral inhibition,” Physiol. Behav.,25, No. 2, 253 (1980).

    Google Scholar 

  5. W. Harkmark, S. I. Mellgren, and B. Srebro, “Acetylcholinesterase histochemistry of the septal region in rat and human: Distribution of enzyme activity,” Brain Res.,95, No. 1–2, 281 (1975).

    Google Scholar 

  6. B. E. Jones and R. Y. Moore, “Ascending projections of the locus coeruleus in the rat. II. Autoradiographic study,” Brain Res.,127, No. 1, 23 (1977).

    Google Scholar 

  7. K. J. Kellar, P. A. Brown, J. Madrid, M. Bernstein, J. Vernikos-Daniellis, and W. R. Mehler, “Origins of serotonin innervation of forebrain structures,” Expt. Neurol., 56, No. 1, 52 (1977).

    Google Scholar 

  8. P. R. Lewis and C. C. D. Shute, “The cholinergic limbic system: projections of hippocampal formation, medial cortex, nuclei of the ascending cholinergic reticular system, and the subfornical organ and supra-optic crest,” Brain,90, No. 3, 526 (1967).

    Google Scholar 

  9. O. Lindvall and U. Steveni, “Dopamine and noradrenaline neurons projecting to the septal area in the rat,” Cell. Tiss. Res.,190, No. 3, 383 (1978).

    Google Scholar 

  10. M. Palkovits, “Neuronal pathways and neurotransmitters in septum pellucidum of rat (short review),” Endocrinol. Expt.,10, No. 3, 225 (1976).

    Google Scholar 

  11. P. Poulain, “Excitation des neurons de la region preoptico-septal par application iontophoretique d'acetylcholine,” C. R. Acad. Sci.,279, 1773 (1974).

    Google Scholar 

  12. M. Segal, “Responses of septal nuclei neurons to microiontophoretically administered putative neurotransmitters,” Life Sci.,14, No. 7, 1345 (1974).

    Google Scholar 

  13. B. Srebro, S. I. Mellgren, and W. Harkmark, Ed. J. F. De France, “Acetylcholinesterase histochemistry of the septal region in the rat,” in: The Septal Nuclei, Plenum Press, New York-London (1976), p. 65.

    Google Scholar 

  14. C. H. Vanderwolf, “Neocortical and hippocampal activation in relation to behaviour: Effects of atropine, eserine, phenothiazine and amphetamine,” J. Comp. Physiol. Psychol.,88, No. 1, 300 (1975).

    Google Scholar 

  15. O. S. Vinogradova, E. S. Brazhnik, A. M. Karanov, and S. D. Zhadina, “Analysis of neuronal activity in rabbit's septum with various conditions of deafferentation,” Brain Res.,187, No. 2, 354 (1980).

    Google Scholar 

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Authors and Affiliations

  1. Institute of Biological Physics, Academy of Sciences of the USSR, Pushchino

    S. D. Zhadina & O. S. Vinogradova

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  1. S. D. Zhadina
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  2. O. S. Vinogradova
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Translated from Zhurnal Vysshei Nervnoi Deyatel'nosti imeni I, P. Pavlova, Vol. 32, No. 2, pp. 319–326, March–April, 1983.

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Zhadina, S.D., Vinogradova, O.S. Effects of acetylcholine, norepinephrine, and serotonin on neurons of the septumin vitro . Neurosci Behav Physiol 13, 405–411 (1983). https://doi.org/10.1007/BF01182682

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  • DOI: https://doi.org/10.1007/BF01182682

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