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Sequence similarity between part of human retinoblastoma susceptibility gene product and a neurofilament protein subunit

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Bioscience Reports

Abstract

Retinoblastoma, is a highly malignant but readily treatable cancer of the retina, which occurs at an incidence of 1 in 20,000 live births in young children. The retinoblastoma gene that determines susceptibility to this cancer encodes a nuclear phosphoprotein which has been extensively characterized. Yet, to this date, its function remains unknown. We report here that RB amino acids 307–435 shows similarity to the rod domain of the neurofilament L-type subunit (NF-L).

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Authors and Affiliations

  1. Dept. of Pathology, Univ. of California at St Diego, 92093, La Jolla, CA

    Wen-Hwa Lee

  2. Center for Molecular Medicine/Institute of Biotechnology, The University of Texas Health Science Center at San Antonio, 15255 Lambda Drive, 78245, San Antonio, Texas

    Frank Hong

Authors
  1. Frank Hong
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  2. Wen-Hwa Lee
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Hong, F., Lee, WH. Sequence similarity between part of human retinoblastoma susceptibility gene product and a neurofilament protein subunit. Biosci Rep 11, 159–163 (1991). https://doi.org/10.1007/BF01182484

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  • DOI: https://doi.org/10.1007/BF01182484

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