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Inhibition of CNS myelin developmentin vivo by implantation of anti-GalC hybridoma cells

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Journal of Neurocytology

Summary

Implantation of hybridoma cells that secrete a monoclonal antigalactocerebroside into the dorsal columns of ⩽ 9-day-old rat spinal cord results in failure of development of dorsal column myelin in the vicinity of the implant. Clusters of apparently undamaged amyelinated axons remain among the hybridoma cells. Ventral myelin is unaffected. These in vivo results support antibody-mediated inhibition of myelin formation as a potential mechanism underlying failure of remyelination in multiple sclerosis.

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Authors and Affiliations

  1. Departments of Physiology & Rehabilitation Medicine, New York University School of Medicine, 10016, New York, NY, USA

    J. Rosenbluth, Z. Liu, D. Guo & R. Schiff

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  1. J. Rosenbluth
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  2. Z. Liu
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  3. D. Guo
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  4. R. Schiff
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Rosenbluth, J., Liu, Z., Guo, D. et al. Inhibition of CNS myelin developmentin vivo by implantation of anti-GalC hybridoma cells. J Neurocytol 23, 699–707 (1994). https://doi.org/10.1007/BF01181644

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  • DOI: https://doi.org/10.1007/BF01181644

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