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Transient co-localization of calretinin, parvalbumin, and calbindin-D28k in developing visual cortex of monkey

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Journal of Neurocytology

Summary

This paper reports a double-labelling immunocytochemical study of the three calcium-binding proteins calretinin, parvalbumin, and calbindin-D28k in developing and adultMacaca primary visual cortex. In adult visual cortex, each protein marks a subset of GABAergic neurons with a characteristic laminar distribution and virtually no co-localization was found between these three proteins, suggesting that each calcium-binding protein may serve as a marker for one or more cortical subcircuits. The immature visual cortex, immunostained using identical techniques was then analysed to determine if each calcium-binding protein could serve as a developmental marker for these circuits. The Cajal-Retzius cells of layer 1 contained all three proteins during development. Calbindin-D28k and calretinin were co-localized starting at Fd (foetal day) 45 and after Fdl25, parvalbumin also was present in the same Cajal-Retzius cells. All three proteins continued to be expressed until the Cajal-Retzius disappeared postnatally. In layers 2–6 calbindin-D28k and calretinin were never co-localized. In contrast, parvalbumin and calretinin were found in neurons of deep layer 3 from Fd 155 to postnatal (P6) weeks with a few persisting even later. Before birth almost all PV+ neurons in layers 4–6 were CaB+, but by P3 weeks only a few PV+/CaB+ neurons remained in layer 4C and these completely disappeared by P6 weeks. Co-localization in layer 4 neurons overlaps the period of ocular dominance segregation, suggesting that the onset of cortical maturity coincides with segregation of calcium-binding proteins within the GABA interneurons.

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Authors and Affiliations

  1. Department of Biological Structure, University of Washington School of Medicine, 98195, Seattle, WA, USA

    Y. -H. Yan, J. F. M. Van Brederode & A. E. Hendrickson

  2. Department of Ophthalmology, University of Washington School of Medicine, 98195, Seattle, WA, USA

    A. E. Hendrickson

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  1. Y. -H. Yan
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  2. J. F. M. Van Brederode
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  3. A. E. Hendrickson
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Yan, Y.H., Van Brederode, J.F.M. & Hendrickson, A.E. Transient co-localization of calretinin, parvalbumin, and calbindin-D28k in developing visual cortex of monkey. J Neurocytol 24, 825–837 (1995). https://doi.org/10.1007/BF01179982

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  • DOI: https://doi.org/10.1007/BF01179982

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