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Transformed steroids

Communication 4. Synthesis, properties, and reactions of 3β, 16α, 17α-trihydroxypregn-5-en-20-one

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Bulletin of the Academy of Sciences of the USSR, Division of chemical science Aims and scope

Summary

  1. 1.

    Various ways of synthesizing 3β,16α,17α-trihydroxypregn-5-en-20-one were investigated, and some of its reactions were studied.

  2. 2.

    3β,16α,17α-Trihydroxypregn-5-en-20-one undergoes D-homo isomerization of the crystalline condition when heated below the melting point and so does not have a true melting point.

  3. 3.

    A study was made of the D-homo isomerization of 3β, 16α,17α-trihydroxypregn-5-en-20-one under acid and alkaline conditions and also over silica gel and in presence of ferric chloride.

  4. 4.

    From the products of the isomerization of 3β,16α,17α-trihydroxypregn-5-en-20-one the previously undescribed 3β,16α17α-trihydroxy-17β-methyl-D-homoandrost-5-en-17a-one was isolated.

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Authors and Affiliations

  1. N. D. Zelinskii Institute of Organic Chemistry, Academy of Sciences, USSR

    V. A. Dubrovskii, A. A. Akhrem & A. V. Kamernitskii

Authors
  1. V. A. Dubrovskii
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  2. A. A. Akhrem
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  3. A. V. Kamernitskii
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Additional information

This article is published in accordance with a resolution of the Conference of Chief Editors of Journals of the Academy of Sciences of the USSR, July 12, 1962, as a dissertation paper by V. A. Dubvorskii.

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Dubrovskii, V.A., Akhrem, A.A. & Kamernitskii, A.V. Transformed steroids. Russ Chem Bull 13, 87–93 (1964). https://doi.org/10.1007/BF01179573

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  • DOI: https://doi.org/10.1007/BF01179573

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