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Aminoacyl derivatives of nucleosides, nucleotides, and polynucleotides

16. Synthesis of dipeptidyl-tRNAs with fluorescent labels

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Bulletin of the Academy of Sciences of the USSR, Division of chemical science Aims and scope

Conclusions

  1. 1.

    The N-hydroxysuccinimide esters of dansylated amino acids (glycine, L-alanine, L-valine, and L-phenylalanine) and β-anthracenesulfonylglycine have been synthesized and characterized.

  2. 2.

    The N-hydroxysuccinimide esters of fluoresceinylaminothiocarbonylglycine and α-naphthylaminocarbonylglycine, which are labile compounds, have been obtained. The structure of the N-hydroxysuccinimide ester of fluoresceinylaminothiocarbonylglycine has been confirmed by a reversed synthesis.

  3. 3.

    The following dipeptidyl-tRNAs with fluorescent labels on the N terminus of the peptide part of the molecule have been synthesized from the N-hydroxysuccinimide esters obtained: dansylaminoacyl-[14C]Phe-tRNA (where aminoacyl may be Gly, L-Ala, L-Val, or L-Phe), β-anthracenylsulfonylglycyl-[14C]Phe-tRNA, fluoresceinylaminothiocarbonyl-[14C]Phe-tRNA, and α-naphthylaminocarbonylglycyl-[14C]Phe-tRNA.

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Authors and Affiliations

  1. Institute of Molecular Biology, Academy of Sciences of the USSR, Moscow

    L. A. Aleksandrova, T. M. Kutuzova, A. A. Kraevskii, M. K. Kukhanova & B. P. Gottikh

Authors
  1. L. A. Aleksandrova
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  2. T. M. Kutuzova
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  3. A. A. Kraevskii
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  4. M. K. Kukhanova
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  5. B. P. Gottikh
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Additional information

For report 15 see [1].

Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 3, pp. 647–653, March, 1977.

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Aleksandrova, L.A., Kutuzova, T.M., Kraevskii, A.A. et al. Aminoacyl derivatives of nucleosides, nucleotides, and polynucleotides. Russ Chem Bull 26, 583–589 (1977). https://doi.org/10.1007/BF01179472

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  • DOI: https://doi.org/10.1007/BF01179472

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